ArticlePLoS genetics2016
Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Altered proteomics in brain extracellular vesicles from depressed individuals who died by suicide implicates synaptic processes.The international journal of neuropsychopharmacology · 2025Article
- Exploration of phosphoproteomic association during epimorphic regeneration.Scientific reports · 2025Article
- Gene and Allele-Specific Expression Underlying the Electric Signal Divergence in African Weakly Electric Fish.Molecular biology and evolution · 2024Article
- Rgs4 is a regulator of mTOR activity required for motoneuron axon outgrowth and neuronal development in zebrafish.Scientific reports · 2021Article
- Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2.EMBO reports · 2021Article
- Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia.eLife · 2021Article
- Hypermethylation-mediated silencing of NDRG4 promotes pancreatic ductal adenocarcinoma by regulating mitochondrial function.BMB reports · 2020Article
- Neural innervation as a potential trigger of morphological color change and sexual dimorphism in cichlid fish.Scientific reports · 2020Article
- Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish.Cellular and molecular life sciences : CMLS · 2020Article
- Nervous NDRGs: the N-myc downstream-regulated gene family in the central and peripheral nervous system.Neurogenetics · 2019Review
- The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones.Cell reports · 2019Article
- NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients.NPJ breast cancer · 2019Article
- GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.The Journal of experimental medicine · 2018Article
- NDRG4 promotes myogenesis via Akt/CREB activation.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axon ensheathment by specialized glial cells is an important process for fast propagation of action potentials. The rapid electrical conduction along myelinated axons is mainly due to its saltatory nature characterized by the accumulation of ion channels at the nodes of Ranvier. However, how these ion channels are transported and anchored along axons is not fully understood. We have identified N-myc downstream-regulated gene 4, ndrg4, as a novel factor that regulates sodium channel clustering in zebrafish. Analysis of chimeric larvae indicates that ndrg4 functions autonomously within neurons for sodium channel clustering at the nodes. Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE/NSF machinery.
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