ArticleMicrobiology (Reading, England)2017
Unravelling the biosynthesis of pyriculol in the rice blast fungus Magnaporthe oryzae.
Article in Microbiology (Reading, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 51 citations in OpenAlex.
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- Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae.Journal of industrial microbiology & biotechnology · 2021Review
- Comparative Genomics Used to Predict Virulence Factors and Metabolic Genes amongJournal of fungi (Basel, Switzerland) · 2021Article
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- Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Analysis of the Secondary Metabolism in Magnaporthe oryzae.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Secondary Metabolites of the Rice Blast FungusInternational journal of molecular sciences · 2020Review
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- Mycovirus-Induced Tenuazonic Acid Production in a Rice Blast FungusFrontiers in microbiology · 2020Article
- Griseaketides A-D, New Aromatic Polyketides from the Pathogenic FungusMolecules (Basel, Switzerland) · 2019Article
- Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products.Journal of the American Chemical Society · 2019Article
- Advances of Metabolomics in Fungal Pathogen-Plant Interactions.Metabolites · 2019Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyriculol was isolated from the rice blast fungus Magnaporthe oryzae and found to induce lesion formation on rice leaves. These findings suggest that it could be involved in virulence. The gene MoPKS19 was identified to encode a polyketide synthase essential for the production of the polyketide pyriculol in the rice blast fungus M. oryzae. The transcript abundance of MoPKS19 correlates with the biosynthesis rate of pyriculol in a time-dependent manner. Furthermore, gene inactivation of MoPKS19 resulted in a mutant unable to produce pyriculol, pyriculariol and their dihydro derivatives. Inactivation of a putative oxidase-encoding gene MoC19OXR1, which was found to be located in the genome close to MoPKS19, resulted in a mutant exclusively producing dihydropyriculol and dihydropyriculariol. By contrast, overexpression of MoC19OXR1 resulted in a mutant strain only producing pyriculol. The MoPKS19 cluster, furthermore, comprises two transcription factors MoC19TRF1 and MoC19TRF2, which were both found individually to act as negative regulators repressing gene expression of MoPKS19. Additionally, extracts of ΔMopks19 and ΔMoC19oxr1 made from axenic cultures failed to induce lesions on rice leaves compared to extracts of the wild-type strain. Consequently, pyriculol and its isomer pyriculariol appear to be the only lesion-inducing secondary metabolites produced by M. oryzae wild-type (MoWT) under these culture conditions. Interestingly, the mutants unable to produce pyriculol and pyriculariol were as pathogenic as MoWT, demonstrating that pyriculol is not required for infection.
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