ArticleMicrobiology (Reading, England)2016
Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.
Article in Microbiology (Reading, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Marine-Derived Rare Actinomycetes: Metabolites and Their Biosynthesis.Marine drugs · 2026Review
- Genome Mining-Driven Isolation of New Gromomycins and Insights into Their Mode of Action.ACS chemical biology · 2026Article
- Marine Bacteria as a Source of Antibiotics AgainstMarine drugs · 2026Review
- Genomic insights into biosynthetic gene cluster diversity and structural variability in marine bacteria.Scientific reports · 2025Article
- Genomic and Metabolomic Insights into Metabolites of aMarine drugs · 2025Article
- dTSR enables efficient improvement of heterologous production of spinosad inSynthetic and systems biotechnology · 2025Article
- Article
- Use of MALDI-TOF mass spectrometry and IDBac to mine for understudied bacterial genera from the environment.ISME communications · 2025Article
- Microbiome profiling and Actinomycetes isolation from tropical marine sponges.AIMS microbiology · 2025Article
- A vast repertoire of secondary metabolites potentially influences community dynamics and biogeochemical processes in cold seeps.Science advances · 2024Article
- Genome sequence ofMicrobiology resource announcements · 2023Article
- Micrococcus spp. as a promising source for drug discovery: A review.Journal of industrial microbiology & biotechnology · 2023Review
- Diversity and taxonomic distribution of bacterial biosynthetic gene clusters predicted to produce compounds with therapeutically relevant bioactivities.Journal of industrial microbiology & biotechnology · 2023Article
- Diversity of Bacterial Secondary Metabolite Biosynthetic Gene Clusters in Three Vietnamese Sponges.Marine drugs · 2022Article
- Expanding the genomic encyclopedia ofCell genomics · 2022Article
- Atmospheric chemosynthesis is phylogenetically and geographically widespread and contributes significantly to carbon fixation throughout cold deserts.The ISME journal · 2022Article
- Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes.Nature microbiology · 2022Article
- Rare actinobacteria isolated from the hypersaline Ojo de Liebre Lagoon as a source of novel bioactive compounds with biotechnological potential.Microbiology (Reading, England) · 2022Article
- Complete Genome Sequence of Two Deep-SeaMarine drugs · 2021Article
- Mining genomes to illuminate the specialized chemistry of life.Nature reviews. Genetics · 2021Review
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10 authors.
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Abstract
Traditional natural product discovery methods have nearly exhausted the accessible diversity of microbial chemicals, making new sources and techniques paramount in the search for new molecules. Marine actinomycete bacteria have recently come into the spotlight as fruitful producers of structurally diverse secondary metabolites, and remain relatively untapped. In this study, we sequenced 21 marine-derived actinomycete strains, rarely studied for their secondary metabolite potential and under-represented in current genomic databases. We found that genome size and phylogeny were good predictors of biosynthetic gene cluster diversity, with larger genomes rivalling the well-known marine producers in the Streptomyces and Salinispora genera. Genomes in the Micrococcineae suborder, however, had consistently the lowest number of biosynthetic gene clusters. By networking individual gene clusters into gene cluster families, we were able to computationally estimate the degree of novelty each genus contributed to the current sequence databases. Based on the similarity measures between all actinobacteria in the Joint Genome Institute's Atlas of Biosynthetic gene Clusters database, rare marine genera show a high degree of novelty and diversity, with Corynebacterium, Gordonia, Nocardiopsis, Saccharomonospora and Pseudonocardia genera representing the highest gene cluster diversity. This research validates that rare marine actinomycetes are important candidates for exploration, as they are relatively unstudied, and their relatives are historically rich in secondary metabolites.
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