Evidence map›Paper›PMID 27902331›Full record

ArticleThe Journal of general virology2016

The plasma virome of febrile adult Kenyans shows frequent parvovirus B19 infections and a novel arbovirus (Kadipiro virus).

Carolyne N Ngoi, Juliana Siqueira, Linlin Li, Xutao Deng, Peter Mugo, Susan M Graham, Matt A Price, Eduard J Sanders, Eric Delwart

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of general virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Article
  8. Blood virosphere in febrile Tanzanian children.Emerging microbes & infections · 2021
    Article
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  18. Viral Metagenomics of Blood Donors and Blood-Derived Products Using Next-Generation Sequencing.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Carolyne N NgoiCentre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Juliana SiqueiraBlood Systems Research Institute, San Francisco, CA, USA.
Linlin LiBlood Systems Research Institute, San Francisco, CA, USA.
Xutao DengBlood Systems Research Institute, San Francisco, CA, USA.
Peter MugoCentre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Susan M GrahamCentre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Matt A PriceInternational AIDS Vaccine Initiative, New York, NY, USA.
Eduard J SandersCentre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Eric DelwartDepartment of Laboratory Medicine, University of California at San Francisco, CA, USA.
Blood Systems Research Institute · USKenya Medical Research Institute · KEInternational AIDS Vaccine Initiative · USUniversity of Oxford · GB

Funding

Int'l Traineeships in AIDS Prevention Studies (ITAPS)R25MH064712 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINDAN, CHRISTINA P · 2002 to 2018
$3.4M
Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
NHLBI NIH HHS R01 HL105770NIMH NIH HHS R25 MH064712Wellcome Trust
6 · The paper itself

Abstract

Viral nucleic acids present in the plasma of 498 Kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. The highest to lowest fraction of plasma pools was positive for parvovirus B19 (75 %), pegivirus C (GBV-C) (67 %), alpha anellovirus (59 %), gamma anellovirus (55 %), beta anellovirus (41 %), dengue virus genotype 2 (DENV-2) (16 %), human immunodeficiency virus type 1 (6 %), human herpesvirus 6 (6 %), HBV (4 %), rotavirus (4 %), hepatitis B virus (4 %), rhinovirus C (2 %), Merkel cell polyomavirus (MCPyV; 2 %) and Kadipiro virus (2 %). Ranking by overall percentage of viral reads yielded similar results. Characterization of viral nucleic acids in the plasma of a febrile East African population showed a high frequency of parvovirus B19 and DENV infections and detected a reovirus (Kadipiro virus) previously reported only in Asian Culex mosquitoes, providing a baseline to compare with future virome studies to detect emerging viruses in this region.

Indexed as

AdultColtivirusDNA, ViralFemaleFeverHumansKenyaMaleParvovirus B19, HumanPhylogenyVirus DiseasesVirusesYoung AdultDNA, Viral

Identifiers

PMID27902331
PMCPMC5203674
OpenAlexW2560754290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.