Evidence map›Paper›PMID 27901585›Full record

ReviewThe American journal of drug and alcohol abuse2017

A review of positron emission tomography studies exploring the dopaminergic system in substance use with a focus on tobacco as a co-variate.

Thulasi Thiruchselvam, Saima Malik, Bernard Le Foll

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of drug and alcohol abuse, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Review
  6. Association between Polymorphism rs1799732 ofInternational journal of environmental research and public health · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys.The Journal of pharmacology and experimental therapeutics · 2020
    Article
  12. Review
  13. A Primer on Foraging and the Explore/Exploit Trade-Off for Psychiatry Research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thulasi Thiruchselvamb Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute , Centre for Addiction and Mental Health , Toronto , ON , Canada.
Saima Malikb Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute , Centre for Addiction and Mental Health , Toronto , ON , Canada.
Bernard Le Folla Addiction Medicine Service, Ambulatory Care and Structured Treatments , Centre for Addiction and Mental Health , Toronto , ON , Canada.
Centre for Addiction and Mental Health · CAUniversity of Toronto · CA

Funding

Impact of nicotine metabolism on brain dopamine transmissionR21DA039453 · NIDA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI LE FOLL, BERNARD · 2015 to 2016
$294k
NIDA NIH HHS R21 DA039453
6 · The paper itself

Abstract

With the evolving sensitivity of positron emission tomography (PET) and the emergence of novel radiotracers, greater insight has been gained into the dopaminergic system as it relates to substance use. In this review, we summarize PET investigations from the last ten years that explore the dopaminergic system in tobacco, alcohol, stimulant, opiates, and cannabis addiction. In light of the prevalence of substance co-use, this review will also explore the effect of tobacco and other substance abuse co-morbidity on the dopaminergic system across study samples in the reviewed literature. In non-dependence, increased DA transmission following acute stimulant administration is a robust and consistent observation but is less detectable following acute alcohol and tobacco, where it likely represents a conditioned effect mediating reward expectation. Chronic drug exposure is generally associated with a hypo-functioning pre-synaptic dopamine system and lower D2/D3 receptor availability relative to healthy controls. Emerging evidence also shows that stimulant use disorders in particular may also be associated with greater D3 receptor availability relative to controls. A defined role for the dopaminergic system in cannabis and opiate use is yet to be elucidated. Future work is also needed to delineate the potential interactive effects of acute and chronic tobacco and substance co-use on the dopaminergic system.

Indexed as

AlcoholismAmphetamine-Related DisordersDopaminergic NeuronsDrug InteractionsFunctional NeuroimagingHumansMarijuana AbuseOpioid-Related DisordersPositron-Emission TomographyTobacco Use DisorderaddictiondopaminenicotinePETtobacco

Identifiers

PMID27901585
PMCPMC5584784
OpenAlexW2559100343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.