Evidence map›Paper›PMID 27901278›Full record

SynthesisThe Cochrane database of systematic reviews2016

Surgery for women with anterior compartment prolapse.

Christopher Maher, Benjamin Feiner, Kaven Baessler, Corina Christmann-Schmid, Nir Haya, Julie Brown

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04010162 (Social Media Awareness Level of Non-urogynecologist Doctors About the Current Mesh Discussions in Urogynecology), which is not on this map. Cited by 100 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 7 pooled it
26.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04010162 unknown statusnot on this mapstarted 2019, after this paper: background citation

Social Media Awareness Level of Non-urogynecologist Doctors About the Current Mesh Discussions in Urogynecology: A Practical Survey Study.

TypeobservationalSponsorUludag UniversityRan2019 to 2019Enrolled1,500ConditionsPelvic Organ Prolapse, Urinary Incontinence, Complication of Surgical ProcedureArmsMesh debate awareness survey
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 7 syntheses or guidelines pooled it, 264 citations in OpenAlex.

  1. T‑shaped sling with modified posterior pelvic reconstruction: a technical note with video vignette.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025
    Pooled it
  2. Transvaginal mesh or grafts or native tissue repair for vaginal prolapse.The Cochrane database of systematic reviews · 2024
    Pooled it
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  4. Pessaries (mechanical devices) for managing pelvic organ prolapse in women.The Cochrane database of systematic reviews · 2020
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Christopher MaherRoyal Brisbane and Women's Hospital, University Queensland, Brisbane, Queensland, Australia.
Benjamin Feiner
Kaven Baessler
Corina Christmann-Schmid
Nir Haya
Julie Brown
Carmel Medical Center · ILCharité - Universitätsmedizin Berlin · DEHillel Yaffe Medical Center · ILRoyal Brisbane and Women's Hospital · AUUniversity of Auckland · NZUniversity of Lucerne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo minimise the rate of recurrent prolapse after traditional native tissue repair (anterior colporrhaphy), clinicians have utilised a variety of surgical techniques.

objectivesTo determine the safety and effectiveness of surgery for anterior compartment prolapse. SEARCH

methodsWe searched the Cochrane Incontinence Group Specialised Register, including the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In Process (23 August 2016), handsearched journals and conference proceedings (15 February 2016) and searched trial registers (1 August 2016). SELECTION CRITERIA: Randomised controlled trials (RCTs) that examined surgical operations for anterior compartment prolapse. DATA COLLECTION AND ANALYSIS: Two review authors independently selected trials, assessed risk of bias and extracted data. Primary outcomes were awareness of prolapse, repeat surgery and recurrent prolapse on examination. MAIN

resultsWe included 33 trials (3332 women). The quality of evidence ranged from very low to moderate. Limitations were risk of bias and imprecision. We have summarised results for the main comparisons. Native tissue versus biological graft Awareness of prolapse: Evidence suggested few or no differences between groups (risk ratio (RR) 0.98, 95% confidence interval (CI) 0.52 to 1.82; five RCTs; 552 women; I AUTHORS'

conclusionsBiological graft repair or absorbable mesh provides minimal advantage compared with native tissue repair.Native tissue repair was associated with increased awareness of prolapse and increased risk of repeat surgery for prolapse and recurrence of anterior compartment prolapse compared with polypropylene mesh repair. However, native tissue repair was associated with reduced risk of de novo SUI, reduced bladder injury, and reduced rates of repeat surgery for prolapse, stress urinary incontinence and mesh exposure (composite outcome).Current evidence does not support the use of mesh repair compared with native tissue repair for anterior compartment prolapse owing to increased morbidity.Many transvaginal polypropylene meshes have been voluntarily removed from the market, and newer light-weight transvaginal meshes that are available have not been assessed by RCTs. Clinicans and women should be cautious when utilising these products, as their safety and efficacy have not been established.

Indexed as

CystoceleFemaleGynecologic Surgical ProceduresHumansPelvic Organ ProlapseRandomized Controlled Trials as TopicRectal ProlapseSecondary PreventionSurgical MeshSuture TechniquesUrinary IncontinenceUterine Prolapse

Identifiers

PMID27901278
PMCPMC6464975
OpenAlexW2558652938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.