Evidence map›Paper›PMID 27901245›Full record

ArticleSao Paulo medical journal = Revista paulista de medicina

Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial.

Renata de Melo Felipe da Silva, André Russowsky Brunoni, Eurípedes Constantino Miguel, Roseli Gedanke Shavitt

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  12. Noninvasive brain stimulation in psychiatric disorders: a primer.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Renata de Melo Felipe da SilvaMD. Doctoral Student, Obsessive-Compulsive Spectrum Disorders Program, Department and Institute of Psychiatry, Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP, Brazil.
André Russowsky BrunoniMD, PhD. Director, Service of Interdisciplinary Neuromodulation (SIN), Department and Institute of Psychiatry, Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Eurípedes Constantino MiguelMD, PhD. Full Professor of Psychiatry, Obsessive-Compulsive Spectrum Disorders Program, Department and Institute of Psychiatry, Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Roseli Gedanke ShavittMD, PhD. Director, Obsessive-Compulsive Spectrum Disorders Program, Department and Institute of Psychiatry, Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CONTEXT AND

objectiveNeuromodulation techniques for treating obsessive-compulsive disorder (OCD) have expanded through greater understanding of the brain circuits involved in this disorder. Transcranial direct current stimulation (tDCS), a non-invasive technique, has been studied as an alternative for treatment-resistant OCD. We describe the design of a clinical trial using tDCS for OCD and report on the outcomes from two patients with primary OCD who were resistant to cognitive-behavioral therapy and to selective serotonin reuptake inhibitors, and who received tDCS in an open manner during the training phase for the study procedures. DESIGN AND

settingMethodological description of a clinical trial using tDCS for treatment-resistant OCD at a university hospital; and a report on two cases.

methodsThe proposed study is randomized, sham-controlled and double-blind. Forty-four patients will be randomized to either active or sham intervention. The active intervention consists of applying an electric current of 2 mA, with the cathode positioned in the region corresponding to the supplementary motor cortex (bilaterally) and the anode positioned in the deltoid. The primary outcome will be the reduction in baseline YBOCS (Yale-Brown Obsessive Compulsive Scale) score at the end of week 4. The secondary outcomes will be depression and anxiety symptoms. Genetic markers, cortical excitability and neurocognitive performance will be investigated.

resultsThe first patient showed significant improvement, whereas the second remained symptomatic after four weeks and after six months. tDCS was well tolerated.

conclusiontDCS for treatment-resistant OCD merits randomized controlled trials that test its effectiveness.

Indexed as

Obsessive-Compulsive DisorderTranscranial Direct Current StimulationAdultDouble-Blind MethodHumansMalePsychiatric Status Rating ScalesRandomized Controlled Trials as TopicReproducibility of ResultsSurveys and QuestionnairesTime FactorsTreatment Outcome

Identifiers

PMID27901245
PMCPMC10871858
OpenAlexW2551013639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.