Observational studyArchives of endocrinology and metabolism
Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications.
Observational study in Archives of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism.Reviews in endocrine & metabolic disorders · 2021Pooled it
- Diagnosis and treatment of hypoparathyroidism: a position statement from the Brazilian Society of Endocrinology and Metabolism.Archives of endocrinology and metabolism · 2018Guideline
- Italian guidelines for the management of adult individuals with post-surgical hypoparathyroidism.Journal of endocrinological investigation · 2026Article
- Clinical Characteristics, Treatment Patterns, and Complications in Permanent Hypoparathyroidism: A Large Retrospective Cross-Sectional Study.Calcified tissue international · 2026Article
- Risk factors of renal complications in childhood-onset non-surgical hypoparathyroidism: a long-term follow-up study.Endocrine · 2026Article
- Hypocalcaemic cardiomyopathy presenting as heart failure exacerbation due to untreated primary hypoparathyroidism.ESC heart failure · 2025Article
- Long-term complications of permanent hypoparathyroidism in adults: prevalence and associated factors.Endocrine · 2024Article
- Article
- Renal complications in chronic hypoparathyroidism - a systematic cross-sectional assessment.Frontiers in endocrinology · 2023Observational
- Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Renal complications and quality of life in postsurgical hypoparathyroidism: a case-control study.Journal of endocrinological investigation · 2022Article
- Intractable hypocalcemic seizures due to hypoparathyroidism.Journal of family medicine and primary care · 2021Article
- Rapidly Developing Cataract in Young Adult Patients: Always a Matter for Further Evaluation.Cureus · 2021Article
- Alternate-day calcium dosing may be an effective treatment option for chronic hypoparathyroidism.Journal of endocrinological investigation · 2020Article
- Hypocalcaemic cardiomyopathy: a description of two cases and a literature review.ESC heart failure · 2020Review
- Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism.Journal of medical biochemistry · 2020Article
- MANAGEMENT OF ENDOCRINE DISEASE: Unmet therapeutic, educational and scientific needs in parathyroid disorders.European journal of endocrinology · 2019Review
- Prevalence of Nephrocalcinosis in Pseudohypoparathyroidism: Is Screening Necessary?The Journal of pediatrics · 2018Article
- Self-report of psychological symptoms in hypoparathyroidism patients on conventional therapy.Archives of endocrinology and metabolism · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. MATERIALS AND
methodsData from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG).
resultsFifty-five patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05).
conclusionsThe reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.