ArticleScientific reports2016
Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Immune response against antibiotic-resistant and antibiotic-sensitive staphylococcus aureus in a rat model of implant infection.Scientific reports · 2025Article
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- Bacterial and host interactions inFrontiers in microbiology · 2025Review
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
- Choosing the right animal model for osteomyelitis research: Considerations and challenges.Journal of orthopaedic translation · 2023Review
- Effect of prophylactic administration of vitamin C in chickens with staphylococcal septic arthritis.Veterinary medicine and science · 2022Article
- A Platelet-Rich Plasma-Derived Biologic ClearsFrontiers in cellular and infection microbiology · 2022Article
- Effect of prophylactic vitamin C administration on the efficiency of florfenicol or sulfadiazine-trimethoprim antimicrobial therapy in chickens with staphylococcal arthritis.Tropical animal health and production · 2021Article
- Maternal vaccination with a type-III glycoconjugate protects mouse neonates against Group B Streptococcus intranasal infection.Scientific reports · 2021Article
- Contemporary Clinical Isolates of Staphylococcus aureus from Pediatric Osteomyelitis Patients Display Unique Characteristics in a Mouse Model of Hematogenous Osteomyelitis.Infection and immunity · 2021Article
- Applicability and implementation of the collagen-induced arthritis mouse model, including protocols (Review).Experimental and therapeutic medicine · 2021Review
- Novel therapeutic interventions towards improved management of septic arthritis.BMC musculoskeletal disorders · 2021Review
- Bacterial toxins in musculoskeletal infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Modeling Early Stages of Bone and Joint Infections Dynamics in Humans: A Multi-Agent, Multi-System Based Model.Frontiers in molecular biosciences · 2020Article
- Silver nanoparticles present high intracellular and extracellular killing against Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2019Article
- Article
- Multidrug-resistantBioMed research international · 2019Article
- A potential key role for alpha-haemolysin ofBone & joint research · 2018Article
- Protective effect of Group B Streptococcus type-III polysaccharide conjugates against maternal colonization, ascending infection and neonatal transmission in rodent models.Scientific reports · 2018Article
- Mouse model of hematogenous implant-relatedProceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is the major cause of human septic arthritis and osteomyelitis, which deserve special attention due to their rapid evolution and resistance to treatment. The progression of the disease depends on both bacterial presence in situ and uncontrolled disruptive immune response, which is responsible for chronic disease. Articular and bone infections are often the result of blood bacteremia, with the knees and hips being the most frequently infected joints showing the worst clinical outcome. We report the development of a hematogenous model of septic arthritis in murine knees, which progresses from an acute to a chronic phase, similarly to what occurs in humans. Characterization of the local and systemic inflammatory and immune responses following bacterial infection brought to light specific signatures of disease. Immunization of mice with the vaccine formulation we have recently described (4C-Staph), induced a strong antibody response and specific CD4+ effector memory T cells, and resulted in reduced bacterial load in the knee joints, a milder general inflammatory state and protection against bacterial-mediated cellular toxicity. Possible correlates of protection are finally proposed, which might contribute to the development of an effective vaccine for human use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.