Evidence map›Paper›PMID 27901060›Full record

Trial reportScientific reports2016

Body composition and bone mineral status in patients with Turner syndrome.

Kun Shi, Li Liu, Yao-Juan He, Duan Li, Lian-Xiong Yuan, Gendie E Lash, Li Li

Abstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Turner syndrome: mechanisms and management.Nature reviews. Endocrinology · 2019
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kun ShiDepartment of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
Li LiuDepartment of Pediatrics Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong 510160, China.
Yao-Juan HeDepartment of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
Duan LiDepartment of Pediatrics Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong 510160, China.
Lian-Xiong YuanDepartment of Biostatistics, Sun Yixian University, 74 Zhong Shan Er Road, Guangzhou, Guangdong, 510515, China.
Gendie E LashGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.
Li LiDepartment of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jingsui Road, Guangzhou, Guangdong, 510160, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body composition and decreased bone mineral status parameters in patients with TS. This study included 24 girls with TS, in which 13 girls exhibited X0 karyotype and 11 had mosaicism. Quantitative ultrasound (QUS) assessed the bone mineral status of the calcaneus, including bone mineral density (BMD), amplitude-dependent speed of sound (AD-SOS), broadband ultrasound attenuation (BUA) and InBody 770 assessed body composition. Pearson's test was performed to correlate measured parameters with patient age. The body composition and bone mineral status parameters were not significantly influenced by patient karyotype. There was a correlation between patient age and AD-SOS (r = -0.61, P = 0.002) and BUA (r = 0.50, P = 0.013) but not BMD (r = -0.19, P = 0.379). In conclusion, there was no effect of karyotype on body composition or body mineral status. Bone mineral status, as evidenced by changes in AD-SOS and BUA, alters with age regardless of karyotype. The developmental trajectory demonstrated in the current study warrants further validation in a longitudinal study.

Indexed as

Body CompositionBone DensityMosaicismTurner SyndromeAdolescentAdultChildFemaleHumans

Identifiers

PMID27901060
PMCPMC5128814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.