Evidence map›Paper›PMID 27901023›Full record

ArticleScientific reports2016

Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91

Yang Wang, Xuegong Fan, Tao Tang, Rong Fan, Chunhu Zhang, Zebing Huang, Weijun Peng, Pingping Gan, Xingui Xiong, Wei Huang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Quinones as Neuroprotective Agents.Antioxidants (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. Blood-Brain Barrier Mechanisms in Stroke and Trauma.Handbook of experimental pharmacology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  19. Rhein Relieves Oxidative Stress in an AβFrontiers in pharmacology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yang WangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Xuegong FanDepartment of Infectious Diseases, Key Laboratory of Viral Hepatitis of Hunan, Xiangya Hospital, Central South University, 410008 Changsha, China.
Tao TangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Rong FanLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Chunhu ZhangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Zebing HuangDepartment of Infectious Diseases, Key Laboratory of Viral Hepatitis of Hunan, Xiangya Hospital, Central South University, 410008 Changsha, China.
Weijun PengDepartment of Integrated Traditional Chinese and Western Medicine, 2nd Xiangya Hospital, Central South University, 410011 Changsha, China.
Pingping GanDepartment of Oncology, Xiangya Hospital, Central South University, 410008 Changsha, China.
Xingui XiongLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Wei HuangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Xi HuangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress chiefly contributes to the disruption of the BBB following traumatic brain injury (TBI). The Chinese herbal medicine rhubarb is a promising antioxidant in treating TBI. Here we performed in vivo and in vitro experiments to determine whether rhubarb and its absorbed bioactive compound protected the BBB after TBI by increasing ZO-1 expression through inhibition of gp91

Indexed as

AnimalsAnthraquinonesAntioxidantsBlood-Brain BarrierBrain EdemaBrain Injuries, TraumaticDrugs, Chinese HerbalMaleMAP Kinase Signaling SystemMatrix Metalloproteinase 9NADPH Oxidase 2Oxidative StressRats, Sprague-DawleyReactive Oxygen SpeciesRheumSignal TransductionAnthraquinonesAntioxidantsCybb protein, ratDrugs, Chinese HerbalMatrix Metalloproteinase 9NADPH Oxidase 2Reactive Oxygen SpeciesrheinTjp1 protein, ratZonula Occludens-1 Protein

Identifiers

PMID27901023
PMCPMC5128794
OpenAlexW2557573522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.