Evidence map›Paper›PMID 27900942›Full record

ArticleClinical nephrology2017

Association between chronic kidney disease and cancer mortality: A report from the ALLHAT.

Dhruti P Chen, Barry R Davis, Lara M Simpson, William C Cushman, Jeffrey A Cutler, Mirela Dobre, Charles E Ford, Gail T Louis, Paul Muntner, Suzanne Oparil and 6 more

Abstract read
In one paragraph

Article in Clinical nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dhruti P Chen
Barry R Davis
Lara M Simpson
William C Cushman
Jeffrey A Cutler
Mirela Dobre
Charles E Ford
Gail T Louis
Paul Muntner
Suzanne Oparil
Linda B Piller
Sara L Pressel
Mark J Sarnak
Paul K Whelton
Jackson T Wright
Mahboob Rahman

Funding

CWRU NEPHROLOGY TRAINING PROGRAMT32DK007470 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI SEDOR, JOHN R. · 1986 to 2019
$2.9M
NIDDK NIH HHS T32 DK007470
6 · The paper itself

Abstract

BACKGROUND/

objectivesChronic kidney disease (CKD) and cancer are both common in older patients; whether CKD increases risk for cancer is unclear. This study evaluated CKD as a risk factor for cancer mortality in a large cohort of hypertensive patients. STUDY

designWe did post-hoc analyses of in-trial and post-trial data from participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). SETTING AND

participantsParticipants were ≥ 55 years old with hypertension and one other additional risk factor for coronary heart disease. PREDICTOR: Baseline estimated glomerular filtration rate (eGFR). OUTCOMES: Cancer mortality was ascertained by cancer-related deaths reported in national databases during and after the trial. Cox proportional hazard models were used to calculate hazard ratios (HRs) adjusted for possible confounders and were stratified by baseline GFR.

resultsParticipants' mean age was 66.9 years. After a mean follow-up of 8.9 years, there were 2,338 reported cancer-related deaths. Participants with GFR < 45 mL/min/1.73 m LIMITATIONS: This is a post hoc analysis of clinical trial data.

conclusionsIn a large cohort of hypertensive patients, GFR < 45 mL/min/1.73 m

Indexed as

Glomerular Filtration RateAgedAntihypertensive AgentsFemaleFollow-Up StudiesHumansHypertensionMaleMiddle AgedNeoplasmsProportional Hazards ModelsRandomized Controlled Trials as TopicRenal Insufficiency, ChronicRisk FactorsAntihypertensive Agents

Identifiers

PMID27900942
PMCPMC13055424

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.