Evidence map›Paper›PMID 27900852›Full record

ArticlePediatric obesity2017

Association of ultrasound-based measures of fetal body composition with newborn adiposity.

S Ikenoue, F Waffarn, K Sumiyoshi, M Ohashi, C Ikenoue, C Buss, D L Gillen, H N Simhan, S Entringer, P D Wadhwa

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Influence of Prenatal Aerobic Exercise on Fetal Morphometry.Maternal and child health journal · 2020
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Origins of obesity in the womb: Fetal adiposity and its determinants.The journal of obstetrics and gynaecology research · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Advances in assessing body composition during pregnancy.European journal of clinical nutrition · 2018
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

S IkenoueDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
F WaffarnDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
K SumiyoshiDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
M OhashiDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
C IkenoueDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
C BussDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
D L GillenDepartment of Statistics, University of California, Irvine, Irvine, CA, USA.
H N SimhanDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
S EntringerDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
P D WadhwaDepartment of Pediatrics, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · USUniversity of Miyazaki · JPKeio University · JPUniversity of Pittsburgh · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR001414NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NIMH NIH HHS R01 MH091351
6 · The paper itself

Abstract

backgroundNewborns exhibit substantial variation in gestational age-adjusted and sex-adjusted fat mass proportion. The antecedent characteristics of fetal body composition that are associated with newborn fat mass proportion are poorly understood.

objectiveThe aim of this study was to determine whether a composite measure of fetal fat mass is prospectively associated with newborn adiposity.

methodsIn a longitudinal study of 109 low-risk pregnancies, fetal ultrasonography was performed at approximately 12, 20 and 30 weeks gestation. Estimated fetal adiposity (EFA) was derived by integrating cross-sectional arm and thigh per cent fat area and anterior abdominal wall thickness. Newborn per cent body fat was quantified by Dual Energy X-Ray Absorptiometry. The association between EFA and newborn per cent body fat was determined by multiple linear regression.

resultsAfter controlling for confounding factors, EFA at 30 weeks was significantly associated with newborn per cent body fat (standardized β = 0.41, p < 0.001) and explained 24.0% of its variance, which was substantially higher than that explained by estimated fetal weight (8.1%). The observed effect was driven primarily by arm per cent fat area.

conclusionsA composite measure of fetal adiposity at 30 weeks gestation may constitute a better predictor of newborn per cent body fat than estimated fetal weight by conventional fetal biometry. Fetal arm fat deposition may represent an early indicator of newborn adiposity. After replication, these findings may provide a basis for an improved understanding of the ontogeny of fetal fat deposition, thereby contributing to a better understanding of its intrauterine determinants and the development of potential interventions.

Indexed as

Absorptiometry, PhotonAdiposityAdultBody CompositionFemaleGestational AgeHumansInfant, NewbornLongitudinal StudiesMalePregnancyProspective StudiesUltrasonography, Prenatalfetal body compositionfetal fat massnewborn adiposityper cent body fat

Identifiers

PMID27900852
PMCPMC5526753
OpenAlexW2557798923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.