ArticleChembiochem : a European journal of chemical biology2017
Peptoid Efficacy against Polymicrobial Biofilms Determined by Using Propidium Monoazide-Modified Quantitative PCR.
Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Preventive Activity of an Arginine-Based Surfactant on the Formation of Mixed Biofilms of Fluconazole-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Article
- A conjugate of chlorin e6 and cationic amphipathic peptoid: a dual antimicrobial and anticancer photodynamic therapy agent.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Article
- Novel Antibacterial Properties of the Human Dental Pulp Multipotent Mesenchymal Stromal Cell Secretome.The American journal of pathology · 2022Article
- Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects onACS infectious diseases · 2022Article
- Development of an Anti-Biofilm Screening Technique Leads to the Discovery of a Peptoid with Efficacy againstACS infectious diseases · 2022Article
- Recent Advances and Opportunities in the Study ofFrontiers in cellular and infection microbiology · 2022Review
- Discovery and Characterization of a Rapidly Fungicidal and Minimally Toxic Peptoid againstACS medicinal chemistry letters · 2021Article
- Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe,Molecules (Basel, Switzerland) · 2021Article
- Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections.International journal of molecular sciences · 2021Review
- Targeting Candida albicans in dual-species biofilms with antifungal treatment reduces Staphylococcus aureus and MRSA in vitro.PloS one · 2021Article
- Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.Frontiers in cellular and infection microbiology · 2020Review
- Fluorinated Aromatic Monomers as Building Blocks To Control α-Peptoid Conformation and Structure.Journal of the American Chemical Society · 2019Article
- Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification.Bioorganic & medicinal chemistry letters · 2018Article
- Synthesis of Antibacterial Nisin⁻Peptoid Hybrids Using Click Methodology.Molecules (Basel, Switzerland) · 2018Article
- Recent Advances in the Synthesis of Peptoid Macrocycles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Review
- Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.Molecules (Basel, Switzerland) · 2017Review
- Exploring the links between peptoid antibacterial activity and toxicity.MedChemComm · 2017Article
- Peptoid Efficacy against Polymicrobial Biofilms Determined by Using Propidium Monoazide-Modified Quantitative PCR.Chembiochem : a European journal of chemical biology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilms containing Candida albicans are responsible for a wide variety of clinical infections. The protective effects of the biofilm matrix, the low metabolic activity of microorganisms within a biofilm and their high mutation rate, significantly enhance the resistance of biofilms to conventional antimicrobial treatments. Peptoids are peptide-mimics that share many features of host defence antimicrobial peptides but have increased resistance to proteases and therefore have better stability in vivo. The activity of a library of peptoids was tested against monospecies and polymicrobial bacterial/fungal biofilms. Selected peptoids showed significant bactericidal and fungicidal activity against the polymicrobial biofilms. This coupled with low cytotoxicity suggests that peptoids could offer a new option for the treatment of clinically relevant polymicrobial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.