ArticleAngewandte Chemie (International ed. in English)2017
High-Frequency Mechanostimulation of Cell Adhesion.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- How do vibration stimulation frequencies affect the nonlinear dynamics and mechanical characterization of breast cancer cells?Biochemistry and biophysics reports · 2026Article
- Photocontrol of Non-Adherent Cell Adhesion via Azobenzene-PEG-Lipid/Cyclodextrin Host-Guest Interactions.International journal of molecular sciences · 2026Article
- Advanced materials and devices strategies of mechanical stimulation for tissue regeneration.Regenerative biomaterials · 2026Review
- 3D hydrogel platform with macromolecular actuators for precisely controlled mechanical forces on cancer cell migration.Nature communications · 2025Article
- Advances in microfluidic platforms for tumor cell phenotyping: from bench to bedside.Lab on a chip · 2025Review
- Photonic control of ligand nanospacing in self-assembly regulates stem cell fate.Bioactive materials · 2024Article
- Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy.Chemical science · 2021Article
- Optoregulated force application to cellular receptors using molecular motors.Nature communications · 2021Article
- Stiffness Tomography of Ultra-Soft Nanogels by Atomic Force Microscopy.Angewandte Chemie (International ed. in English) · 2021Article
- Unidirectional rotating molecular motors dynamically interact with adsorbed proteins to direct the fate of mesenchymal stem cells.Science advances · 2020Article
- Optogenetic control of integrin-matrix interaction.Communications biology · 2019Article
- Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation.Stem cells international · 2019Review
- Dynamic Substrates for Cell Biology.Current opinion in colloid & interface science · 2018Article
- Simultaneous complementary photoswitching of hemithioindigo tweezers for dynamic guest relocalization.Nature communications · 2018Article
- High-Frequency Mechanostimulation of Cell Adhesion.Angewandte Chemie (International ed. in English) · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Cell adhesion is regulated by molecularly defined protein interactions and by mechanical forces, which can activate a dynamic restructuring of adhesion sites. Previous attempts to explore the response of cell adhesion to forces have been limited to applying mechanical stimuli that involve the cytoskeleton. In contrast, we here apply a new, oscillatory type of stimulus through push-pull azobenzenes. Push-pull azobenzenes perform a high-frequency, molecular oscillation upon irradiation with visible light that has frequently been applied in polymer surface relief grating. We here use these oscillations to address single adhesion receptors. The effect of molecular oscillatory forces on cell adhesion has been analyzed using single-cell force spectroscopy and gene expression studies. Our experiments demonstrate a reinforcement of cell adhesion as well as upregulated expression levels of adhesion-associated genes as a result of the nanoscale "tickling" of integrins. This novel type of mechanical stimulus provides a previously unprecedented molecular control of cellular mechanosensing.
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