Evidence map›Paper›PMID 27900700›Full record

Trial reportMusculoskeletal surgery2016

Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial.

R D'Ambrosi, F Palumbo, A Paronzini, V Ragone, R M Facchini

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Musculoskeletal surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Pooled it
  7. Review
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  9. Article
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  14. Review
  15. A Historical Analysis of Randomized Controlled Trials in Rotator Cuff Tears.International journal of environmental research and public health · 2020
    Review
  16. Current Clinical Recommendations for Use of Platelet-Rich Plasma.Current reviews in musculoskeletal medicine · 2018
    Review
  17. Article
  18. The Role of Biologic Therapy in Rotator Cuff Tears and Repairs.Current reviews in musculoskeletal medicine · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R D'AmbrosiU.O. Clinica Ortopedica e Traumatologica, Centro Traumatologico Ortopedico, Università degli Studi di Milano, Milan, Italy. riccardo.dambrosi@hotmail.it.ORCID http://orcid.org/0000-0002-1216-792X
F PalumboU.O. Clinica Ortopedica e Traumatologica, Centro Traumatologico Ortopedico, Università degli Studi di Milano, Milan, Italy.
A ParonziniU.O. Clinica Ortopedica e Traumatologica, Centro Traumatologico Ortopedico, Università degli Studi di Milano, Milan, Italy.
V RagoneIRCCS Policlinico San Donato, San Donato Milanese, Italy.
R M FacchiniU.O. Clinica Ortopedica e Traumatologica, Centro Traumatologico Ortopedico, Università degli Studi di Milano, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResults on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions.

methodsThis was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2-C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery. Pain measured by VAS was evaluated preoperatively and 7 and 30 days after surgery.

resultsThe two groups did not differ significantly by age, sex, and dominance of the affected side. In all surgical procedures, a long head of the biceps tenotomy and single-row repair were performed. The preoperative VAS was 5.6 ± 2.4 in PRP group and 6.4 ± 1.5 in the control group (p > 0.05). The group supplemented with PRP reported a VAS significantly better in the first week (2.5 ± 1.9 vs 5.3 ± 2.1, p < 0.05) and during the first month after surgery (1.5 ± 1.0 vs 3.2 ± 1.7, p < 0.05) compared to the control group. The preoperative Constant and DASH scores were 39.95 ± 12 and 51 ± 15.2, respectively, in the PRP group and 41 ± 11 (p > 0.05) and 45 ± 12.6 (p > 0.05) in the control group. The average Constant score improved significantly after 6 months to 81 ± 11.2 (p < 0.05) in the PRP group and 78.5 ± 9 (p < 0.05) in the control group. No differences were noted between the two groups (p > 0.05). The DASH score after 6 months was 17.4 ± 8 (p < 0.05) for the treatment group (the PRP group) and 21 ± 8.4 (p < 0.05) for the control group. No statistically significant differences were found as regards the DASH score in the two groups after 6 months (p > 0.05). The two groups showed no differences in the ultrasound evaluation after 6 months either. No re-ruptures occurred in either group.

conclusionsPRP leads to a reduction in pain during a short-term follow-up. Pain reduction allows for a more rapid recovery of mobilization and improvement in functionality. LEVEL OF EVIDENCE: Randomized controlled trial, Level of evidence, 1.

Indexed as

ArthroscopyPlatelet-Rich PlasmaAgedDouble-Blind MethodFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRange of Motion, ArticularRotator Cuff InjuriesTreatment OutcomeWound HealingFull-thicknessPlatelet-rich plasmaRegenerative medicineRotator cuff tearsShoulder arthroscopyUltrasound evaluation

Identifiers

PMID27900700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.