Evidence map›Paper›PMID 27900613›Full record

ArticleJournal of assisted reproduction and genetics2017

Associations between follicular fluid high density lipoprotein particle components and embryo quality among in vitro fertilization patients.

K Kim, M S Bloom, R W Browne, E M Bell, R M Yucel, V Y Fujimoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. An Updated Understanding of Human Embryonic Fragmentation.Reproductive sciences (Thousand Oaks, Calif.) · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Effect of hyperlipidemia on the outcome ofFrontiers in endocrinology · 2023
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

K KimDepartment of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA.
M S BloomDepartment of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA. mbloom@albany.edu.
R W BrowneDepartment of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
E M BellDepartment of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA.
R M YucelDepartment of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY, USA.
V Y FujimotoDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, USA.

Funding

Developmental Infrastructure CoreR24HD044943 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI GAGE, TIMOTHY B · 2004 to 2016
$4.8M
High Density Lipoprotein (HDL) in Follicular Fluid and Fertility OutcomesR21AG031957 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FUJIMOTO, VICTOR YUTAKA · 2010 to 2011
$443k
6 · The paper itself

Abstract

purposeFollicular redox balance is likely to be important for embryo quality during in vitro fertilization (IVF), and the anti-oxidative high desity lipoprotein (HDL) particle is the sole lipoprotein measured in follicular fluid (FF). Therefore, we investigated FF HDL particle components as predictors of embryo quality during IVF.

methodsTwo research follicles collected from each participant were individually tracked, and 103 women having at least one developed embryo were included in the analysis. Concentrations of 15 non-cholesterol HDL particle components and 26 HDL-cholesterol (HDL-C) particle size subfractions were determined. Embryo quality was assessed for embryo cell number, embryo fragmentation, and embryo symmetry. Multivariable Poisson regression with a sandwich variance estimator was used to evaluate associations between HDL particle components and embryo quality, adjusted for covariates.

resultsHigher γ-tocopherol concentration was associated with less embryo fragmentation (relative risk [RR] = 4.43; 95 % confidence interval [CI] 1.78, 11.06), and higher apolipoprotein A-1 concentration was associated with full embryo symmetry (RR = 3.92; 95 % CI 1.56, 9.90). Higher concentrations of HDL-C subfractions in the large and medium particle size ranges were associated with poorer embryo quality.

conclusionsFF HDL lipophilic micronutrients and protein components, as well as HDL-C particle size, may be important predictors of embryo quality during IVF.

Indexed as

Fertilization in VitroAdultApolipoprotein A-IEmbryonic DevelopmentFemaleFollicular FluidHumansLipoproteins, HDLOvarian FolliclePregnancyTocopherolsApolipoprotein A-ILipoproteins, HDLTocopherolsEmbryo cell number (ECN)Embryo fragmentation score (EFS)Embryo symmetry score (ESS)Follicular fluid (FF)High density lipoprotein (HDL)in vitro fertilization (IVF)

Identifiers

PMID27900613
PMCPMC5237431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.