ArticleObesity surgery2017
Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue.
Article in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Pooled it
- Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis.Obesity surgery · 2019Pooled it
- Is AMP-activated protein kinase activation a central mechanism of cardio-metabolic outcomes after metabolic and bariatric surgery?Diabetes, obesity & metabolism · 2026Review
- TNF/TNFR1 is a Key Regulator of Prolonged Fasting-Induced Decrease in Adipose Tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Metabolic Recovery with the Persistence of Proinflammatory Leucocyte Dysfunction After Bariatric Intervention for Obesity.Obesity surgery · 2024Article
- Impact of Bariatric Surgery on Adipose Tissue Biology.Journal of clinical medicine · 2021Review
- Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity.Diabetology & metabolic syndrome · 2021Article
- Article
- The immune remodel: Weight loss-mediated inflammatory changes to obesity.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Splenectomy fails to attenuate immuno-hematologic changes after rodent vertical sleeve gastrectomy.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Changes in Myokines in Youths With Severe Obesity Following Roux-en-Y Gastric Bypass Surgery.JAMA surgery · 2019Article
- Bariatric Surgery and Precision Nutrition.Nutrients · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype after bariatric surgery.
methodsThirty-one severely obese patients (BMI ≥ 40 kg/m
resultsAfter surgery, mean BMI decreased from 46.1 ± 6.3 to 31.1 ± 5.7 kg/m
conclusionsGene expression patterns in SAT 1 year after bariatric surgery point to a reduced inflammation. The unexpected high TNF expression in SAT of post-obese subjects is most likely not an indicator for inflammation, but rather an indicator for increased lipolysis and adipose tissue catabolism. Notably, after bariatric surgery SAT gene expression reflects a cachexia-like phenotype and differs from the lean state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.