ArticleClinical rheumatology2017
Treatable renal disease in children with silent lupus nephritis detected by baseline biopsy: association with serum C3 levels.
Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Silent lupus nephritis: a pediatric center experience of baseline kidney biopsies and review of the published evidence.Pediatric nephrology (Berlin, Germany) · 2025Pooled it
- Kidney biopsy guidebook 2020 in Japan.Clinical and experimental nephrology · 2021Guideline
- Expert collaborative evidence-based consensus for childhood lupus nephritis diagnosis and treatment: unifying clinical approach in Saudi Arabia.Pediatric rheumatology online journal · 2026Article
- Childhood-Onset Systemic Lupus Erythematosus Research over the Past Decade in Japan.Children (Basel, Switzerland) · 2026Review
- Translating the 2024 ACR lupus nephritis guidelines to pediatric practice.Frontiers in pediatrics · 2026Review
- New Insights on Childhood Lupus Nephritis.International journal of nephrology and renovascular disease · 2025Review
- Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status.Frontiers in cardiovascular medicine · 2024Article
- Does kidney biopsy in pediatric lupus patients "complement" the management and outcomes of silent lupus nephritis? Lessons learned from a pediatric cohort.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis.Annals of the rheumatic diseases · 2022Article
- Influence of air pollution on renal activity in patients with childhood-onset systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2020Article
- Lupus nephritis.Nature reviews. Disease primers · 2020Review
- The role of the alternative pathway of complement activation in glomerular diseases.Clinical and experimental medicine · 2018Review
- Urinary interleukin 22 binding protein as a marker of lupus nephritis in Egyptian children with juvenile systemic lupus erythematosus.Clinical rheumatology · 2018Article
- [Risk factors and prognosis of pediatric silent lupus nephritis with class Ⅲ to Ⅴ].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lupus nephritis is identified in up to 75% of patients with juvenile systemic lupus erythematosus and may present with abnormal urinary findings (overt lupus nephritis) or be apparent only upon renal biopsy (silent lupus nephritis). We investigated whether serum complement levels correlate with renal pathology in pediatric patients with silent lupus nephritis. We performed baseline renal biopsy in 45 children diagnosed with juvenile systemic lupus erythematosus who were admitted to Kagoshima University Hospital between January 2000 and June 2015. Patients were classified as having overt or silent lupus nephritis based on urinary findings at renal biopsy. Silent lupus nephritis was identified in 55.5% (25/45) of cases. Of these, 6 (13.3%) were classified as class III nephritis, according to the International Society of Nephrology/Renal Pathology Society criteria. Decreased serum C3 levels were associated with the renal pathology classification for patients with silent but not with overt lupus nephritis. No differences in serum C4 levels were identified between cases of silent and overt lupus nephritis. Baseline renal biopsy is a critical component of the work-up of juvenile systemic lupus erythematosus as treatable renal pathology may be present in the absence of urinary signs. Serum C3 may be an important marker of the progression of silent lupus nephritis.
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