Evidence map›Paper›PMID 27900437›Full record

ArticleExperimental brain research2017

BDNF and LTP-/LTD-like plasticity of the primary motor cortex in Gilles de la Tourette syndrome.

L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini and 3 more

Abstract read
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In one paragraph

Article in Experimental brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

L MarsiliDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
A SuppaDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
F Di StasioIRCCS Neuromed Institute, Pozzilli, IS, Italy.
D BelvisiIRCCS Neuromed Institute, Pozzilli, IS, Italy.
N UpadhyayDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
I BerardelliDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
M PasquiniDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
S PetrucciDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
M GinevrinoNeurogenetics Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
G FabbriniDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
F CardonaDepartment of Pediatrics and Child Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
G DefazioDepartment of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
A BerardelliDepartment of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy. alfredo.berardelli@uniroma1.it.ORCID 0000-0001-9903-5550
Istituto Neurologico Mediterraneo · ITSapienza University of Rome · ITFondazione Santa Lucia · ITUniversity of Bari Aldo Moro · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects. In GTS patients, motor and psychiatric (OCD) symptom severity was rated using the Yale Global Tic Severity Scale (YGTSS) and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). We compared M1 iTBS-/cTBS-induced plasticity in healthy subjects and in patients with GTS. We also compared responses to TBS according to BDNF polymorphism (Val/Val vs Met carriers) in patients and controls. Fourteen healthy subjects and 13 GTS patients were Met carriers. When considering the whole group of controls, as expected, iTBS increased whereas cTBS decreased MEPs. Differently, iTBS/cTBS failed to induce LTP-/LTD-like plasticity in patients with GTS. When comparing responses to TBS according to BDNF polymorphism, in healthy subjects, Met carriers showed reduced MEP changes compared with Val/Val individuals. Conversely, in patients with GTS, responses to iTBS/cTBS were comparable in Val/Val individuals and Met carriers. YGTSS and Y-BOCS scores were comparable in Met carriers and in Val/Val subjects. We conclude that iTBS and cTBS failed to induce LTP-/LTD-like plasticity in patients with GTS, and this was not affected by BDNF genotype.

Indexed as

AdolescentAdultAgedBrain-Derived Neurotrophic FactorCase-Control StudiesElectromyographyEvoked Potentials, MotorFemaleHumansMaleMiddle AgedMotor CortexNeuronal PlasticityPolymorphism, Single NucleotidePsychiatric Status Rating ScalesSeverity of Illness IndexBrain-Derived Neurotrophic FactorBrain-derived neurotrophic factorCortical plasticityPrimary motor cortexTheta-burst stimulationTourette syndrome

Identifiers

PMID27900437
OpenAlexW2559583815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.