ArticleMuscles, ligaments and tendons journal
Association of ACL tears and single nucleotide polymorphisms in the collagen 12 A1 gene in the Indian population - a preliminary case-control study.
Article in Muscles, ligaments and tendons journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- COL12A1 rs970547 Polymorphism Does Not Alter Susceptibility to Anterior Cruciate Ligament Rupture: A Meta-Analysis.Frontiers in genetics · 2021Pooled it
- Preliminary identification of somatic mutations profile in ACL injury.Scientific reports · 2024Article
- Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study.Sports medicine - open · 2022Article
- Association ofBiomedicines · 2022Article
- Collagen XII Deficiency Increases the Risk of Anterior Cruciate Ligament Injury in Mice.Journal of clinical medicine · 2021Article
- Correlations Between the Genetic Variations in theJournal of athletic training · 2020Article
- Comment on: "Genetic Variants and Anterior Cruciate Ligament Rupture: A Systematic Review".Sports medicine (Auckland, N.Z.) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic predisposition to ACL tears has received tremendous interest in the past few years with many SNPs of different genes being linked to ACL tear. STUDY
objectivesTo examine if specific sequence variants in COL12A1 gene are associated with ACL tears in Indian population. STUDY
designCase-control study. MATERIALS AND
methods50 patients with surgically diagnosed ACL tear and 52 healthy, age-matched controls without any ligament/tendon injuries were genotyped for rs970547 and rs240736 SNPs using real time PCR method.
resultsThe AG and GG genotypes were significantly under-represented in study group patients in rs970547 region (p=0.0361). However, there was no significant difference in genotype/allele frequencies in the rs240736 region.
conclusionsThe COL12A1 rs970547 SNP is associated with ACL tears in the Indian population. However, these results need to be validated further so that predisposed individuals can be screened in the future for counselling and intervention. LEVEL OF EVIDENCE: III.
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