ArticleBMJ open sport & exercise medicine2015
The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: a randomised feasibility study.
Article in BMJ open sport & exercise medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Effectiveness of exercise interventions in patients with colorectal cancer during adjuvant chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Effectiveness of aerobic exercise intervention on cardiovascular disease risk in female breast cancer: a systematic review with meta-analyses.BMC public health · 2024Pooled it
- The effectiveness of physical activity interventions using activity trackers during or after inpatient care: a systematic review and meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2022Pooled it
- Physical Activity: A Systematic Review to Inform Nurse Recommendations During Treatment for Colorectal Cancer.Clinical journal of oncology nursing · 2021Pooled it
- Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate.BMC cancer · 2021Pooled it
- Effects of high-intensity training on the quality of life of cancer patients and survivors: a systematic review with meta-analysis.Scientific reports · 2021Pooled it
- Exercise for women receiving adjuvant therapy for breast cancer.The Cochrane database of systematic reviews · 2016Pooled it
- Physical deterioration and adaptive recovery in physically inactive breast cancer patients during adjuvant chemotherapy: a randomised controlled trial.Scientific reports · 2020Trial
- Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial.Breast cancer research and treatment · 2018Trial
- Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer.International journal of colorectal disease · 2018Trial
- Innovative Exercise in Routine Cancer Care: Insights from Eight Years of Integrated Oncological Exercise Therapy (OTT).Sports medicine - open · 2026Article
- Clarifying the Application of HIIT in Oncology Settings: a Response to "High-Intensity Interval Training for Cancer Patients: Taking Training Progression, Feasibility, and Patient Preferences into Account".Sports medicine (Auckland, N.Z.) · 2025Article
- High-Intensity Interval Training for Cancer Patients: A Review of Key Considerations for Exercise Prescription.Sports medicine (Auckland, N.Z.) · 2025Article
- Physical exercise as a potential adjuvant therapy: effects on inflammation and nutrition in colorectal cancer patients-a systematic review and meta-analysis.Frontiers in nutrition · 2025Review
- Qualitative exploration of the perceptions of exercise in patients with cancer initiated during chemotherapy: a meta-synthesis.BMJ open · 2023Review
- Harms of exercise training in patients with cancer undergoing systemic treatment: a systematic review and meta-analysis of published and unpublished controlled trials.EClinicalMedicine · 2023Article
- Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy-a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Exercise, cancer and cardiovascular disease: what should clinicians advise?Cardiovascular endocrinology & metabolism · 2021Review
- Review
- Effect of a Pedometer-based Exercise Program on Cancer Related Fatigue and Quality of Life amongst Patients with Breast Cancer Receiving Chemotherapy.Asian Pacific journal of cancer prevention : APJCP · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnti-neoplastic treatment is synonymous with an inactive daily life for a substantial number of patients. It remains unclear what is the optimal setting, dosage and combination of exercise and health promoting components that best facilitate patient adherence and symptom management in order to support cardio-respiratory fitness and lifestyle changes in an at-risk population of pre-illness physically inactive cancer patients.
methodsPatients with breast or colon cancer referred to adjuvant chemotherapy and by the oncologists pre-screening verified as physically inactive were eligible to enter a randomised three-armed feasibility study comparing a 12-week supervised hospital-based moderate to high intensity exercise intervention or alternate an instructive home-based12-week pedometer intervention, with usual care.
resultsUsing a recommendation based physical activity screening instrument in order to correspond with cardio-respiratory fitness (VO2 peak) proved to be an applicable method to identify pre-illness physically inactive breast and colon cancer patients. The study demonstrated convincing recruitment (67%), safety and intervention adherence among breast cancer patients; while the attendance rate for colon cancer patients was notably lower (33%). VO2-peak declined on average 12% across study groups from baseline to 12 weeks though indices towards sustaining watt performance and reduce fat mass favoured the hospital-based intervention. Pedometer use was well adapted in both breast and colon cancer patients.
conclusionsDespite a fair adherence and safety, the current study calls into question whether aerobic exercise, regardless of intensity, is able to increase VO2-peak during texane-based chemotherapy in combination with Neulasta in physically inactive breast cancer patients.
trial registrationISRCTN24901641.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.