Evidence map›Paper›PMID 27900109›Full record

ArticleBMJ open sport & exercise medicine2015

Athletes with higher VO

André L L Bachi, Ana Paula R Sierra, Francisco J O Rios, Danieli A Gonçalves, Nabil Ghorayeb, Ronaldo L Abud, Angélica B Victorino, Juliana M B Dos Santos, Maria Augusta D P Kiss, Tania C Pithon-Curi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open sport & exercise medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22International journal of environmental research and public health · 2020
    Trial
  3. Trial
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

André L L BachiDepartment of Microbiology and Immunology, Federal University of São Paulo, São Paulo, Brazil; Institute of Physical Activity Sciences and Sports, Post-Graduate Program in Human Movement Sciences, Cruzeiro do Sul University, São Paulo, Brazil.
Ana Paula R SierraSchool of Physical Education and Sports, University of São Paulo , São Paulo , Brazil.
Francisco J O RiosDepartment of Immunology , Institute of Biomedical Sciences, University of São Paulo , São Paulo , Brazil.
Danieli A GonçalvesFaculty Metodo of São Paulo, São Paulo , Brazil.
Nabil GhorayebDante Pazzanese Institute of Cardiology , São Paulo , Brazil.
Ronaldo L AbudInstitute of Preventive Medicine of São Paulo , São Paulo , Brazil.
Angélica B VictorinoDepartment of Neurology and Neurosurgery , Federal University of São Paulo , São Paulo , Brazil.
Juliana M B Dos SantosDepartment of Otorhinolaryngology , Federal University of São Paulo , São Paulo , Brazil.
Maria Augusta D P KissSchool of Physical Education and Sports, University of São Paulo , São Paulo , Brazil.
Tania C Pithon-CuriInstitute of Physical Activity Sciences and Sports, Post-Graduate Program in Human Movement Sciences, Cruzeiro do Sul University , São Paulo , Brazil.
Mauro VaisbergDepartment of Otorhinolaryngology , Federal University of São Paulo , São Paulo , Brazil.
Universidade Federal de São Paulo · BRUniversidade de São Paulo · BRInstituto Dante Pazzanese de Cardiologia · BRUniversidade Cruzeiro do Sul · BRUniversidade Metodista de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring a session of prolonged and exhaustive exercise, such as a marathon race, large quantities of free radicals are produced and can oxidise (ox) several molecules, such as low-density lipoprotein (LDL). To prevent oxidative damage, athletes present higher antioxidant levels. However, the effect of marathon running on the natural IgM or IgG anti-oxLDL autoantibodies is not understood. Thus, we investigated the effect of a marathon race on oxidative stress and the mechanisms of control of this stress.

methodsBlood samples of 20 marathon runners were collected 24 hours before, immediately and 72 hours after a marathon race to evaluate: plasma lipid profile; serum levels of oxLDL and anti-oxLDL autoantibodies (IgM and IgG isotype) and total antioxidant capacity (TAC). Maximum oxygen uptake (VO2max) was also determined.

resultsImmediately after the race, oxLDL and TAC levels decreased in comparison to the basal levels; however, the IgM or IgG anti-oxLDL levels remain unchanged. Whereas no differences were observed in the IgM or IgG anti-oxLDL levels 72h after the marathon, the oxLDL and TAC levels returned to the basal values. Significant positive correlations were observed between oxLDL and LDL-cholesterol before, and 72h after the marathon. Significant negative correlations were observed between oxLDL and VO2max immediately after the marathon and 72 h later, as well as between oxLDL and TAC 72 h after the race.

conclusionsAthletes with a higher VO2max and total antioxidant activity presented reduced LDL oxidation. The levels of IgM or IgG anti-oxLDL autoantibodies were not affected by running the marathon.

Indexed as

autoantibodiescoronary artery diseasesexhaustive exerciseoxidized LDLtotal antioxidant capacity

Identifiers

PMID27900109
PMCPMC5117006
OpenAlexW2336424363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.