ArticleKorean journal of family medicine2016
Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women.
Article in Korean journal of family medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study.Reproductive biology and endocrinology : RB&E · 2020Trial
- Adaptation of mtDNA content to endurance training, a cross-sectional study and an endurance training intervention.European journal of applied physiology · 2026Article
- Design and methods of a randomized telehealth-based intervention to improve fitness in survivors of childhood cancer with exercise intolerance.Contemporary clinical trials · 2023Article
- Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- Telomere Length and Mitochondrial DNA Copy Number Variations in Patients with Obesity: Effect of Diet-Induced Weight Loss-A Pilot Study.Nutrients · 2022Article
- Flavanol-Rich Cocoa Supplementation Inhibits Mitochondrial Biogenesis Triggered by Exercise.Antioxidants (Basel, Switzerland) · 2022Article
- Evaluating the effects of carbon monoxide releasing molecule-2 against myocardial ischemia-reperfusion injury in ovariectomized female rats.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Article
- Mitochondria-DNA copy-number and incident venous thromboembolism among middle-aged women: a population-based cohort study.Journal of thrombosis and thrombolysis · 2021Article
- PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Measurement of mitochondrial DNA copy number in dried blood spots: A pilot study.Mitochondrion · 2021Article
- Mitochondrial DNA lesions and copy number are strain dependent in endurance-trained mice.Physiological reports · 2020Article
- The Role of Nutri(epi)genomics in Achieving the Body's Full Potential in Physical Activity.Antioxidants (Basel, Switzerland) · 2020Review
- Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults.PloS one · 2020Article
- Associations of blood mitochondrial DNA copy number with social-demographics and cancer risk: results from the Mano-A-Mano Mexican American Cohort.Oncotarget · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies suggest that habitual exercise can improve skeletal mitochondrial function; however, to date, the association between exercise and mitochondrial function in peripheral leukocytes has not been reported. The aim of this study was to evaluate the relationship between regular exercise and mitochondrial function by measuring leukocyte mitochondrial DNA (mtDNA) copy number in postmenopausal women.
methodsThis cross-sectional study included 144 relatively healthy, non-diabetic, non-smoking, postmenopausal women. Clinical parameters, including anthropometric measurements and cardio-metabolic parameters, were assessed. Regular exercise was defined as at least 150 minutes per week of moderate-intensity activity, or an equivalent combination of moderate and vigorous-intensity activity, over a duration of at least 6 months. Leukocyte mtDNA copy numbers were measured using real-time polymerase chain reaction assays, and these were normalized to the β-globin copy number to give the relative mtDNA copy number.
resultsThe mtDNA copy number of peripheral leukocytes was significantly greater in the exercise group (1.33±0.02) than in the no exercise group (1.05±0.02, P<0.01). Stepwise multiple regression analysis showed that regular exercise was independently associated with mtDNA copy number (β=0.25, P<0.01) after adjusting for the variables age, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, homeostasis model assessment of insulin resistance value, and levels of high-density lipoprotein cholesterol, triglycerides, and homocysteine.
conclusionRegular exercise is associated with greater leukocyte mtDNA copy number in postmenopausal women.
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