Evidence map›Paper›PMID 27899984›Full record

ArticleOncology letters2016

Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN.

Hao Zhang, Yang Wang, Tianming Xu, Chen Li, Jiang Wu, Qianyun He, Guangchao Wang, Chen Ding, Kang Liu, Hao Tang and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. MicroRNA-30a-3p Influences Milk Fat Metabolism by TargetingAnimals : an open access journal from MDPI · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. miR-148a-3p promotes rabbit preadipocyte differentiation by targeting PTEN.In vitro cellular & developmental biology. Animal · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hao ZhangDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Yang WangDepartment of Orthopedics, General Hospital of Beijing Military Region, Beijing 100700, P.R. China.
Tianming XuDepartment of Orthopedics, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China.
Chen LiDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Jiang WuDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Qianyun HeDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Guangchao WangDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Chen DingDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Kang LiuDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Hao TangDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Fang JiDepartment of Orthopedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China.
Second Military Medical University · CNChanghai Hospital · CNThe Military General Hospital of Beijing PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma is the most common type of primary malignant bone tumor, and deregulated microRNAs (miRNAs or miRs) in osteosarcoma have attracted great attention. In the present study, through miRNA microarray analysis, it was identified that miR-148a expression was significantly increased in osteosarcoma tissues. Increased miR-148a expression was significantly correlated with tumor progression and prognosis. Furthermore, increased miR-148a expression could promote osteosarcoma growth

Indexed as

microRNAmiR-148aosteosarcomaPI3KproliferationPTEN

Identifiers

PMID27899984
PMCPMC5103920
OpenAlexW2510952075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.