ArticleJournal of geriatric cardiology : JGC2016
Detailed analysis of the impact of age on the QT interval.
Article in Journal of geriatric cardiology : JGC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 79 citations in OpenAlex.
- Cardiac safety of bedaquiline, delamanid and moxifloxacin co-administered with or without varying doses of sutezolid or delpazolid for the treatment of drug-susceptible TB.The Journal of antimicrobial chemotherapy · 2025Trial
- QT prolongation in the STREAM Stage 1 Trial.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Trial
- Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border.Antimicrobial agents and chemotherapy · 2021Trial
- The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.Aging cell · 2026Review
- QT Prolongation and Arrhythmias in Cancer Therapy: A Narrative Review of Mechanistic and Clinical Studies.Cardiovascular toxicology · 2026Review
- From Empirical to More Precise Correction: Multidimensional Performance Evaluation of QTc Formulas in a Cohort of Healthy Asian Youth.Journal of the American Heart Association · 2026Article
- The Moderating Effect of Physical Activity Between IQOS Smoking and Ventricular Repolarization Parameters in Lebanese University Students.Health science reports · 2026Article
- Aging-Induced QT Prolongation as a Potential Contributor to Longevity.Journal of cardiovascular development and disease · 2026Review
- A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.Circulation · 2025Article
- Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation.Journal of molecular and cellular cardiology plus · 2025Article
- Heart Failure, Kidney Function, and Elderly Age, Rather than Levofloxacin Therapy, Are Associated with QTc Prolongation in COVID-19 Patients.Journal of clinical medicine · 2025Article
- Large-Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital-Based Controls and Moxifloxacin-Treated Cases.Clinical and translational science · 2025Article
- Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization.Nature cardiovascular research · 2025Article
- Predictive Analysis of Non-Cardiac Drug-Induced QTc Interval Prolongation: A Cross-Sectional Study.Clinical pharmacology : advances and applications · 2025Article
- Temporal variations in QTc interval during and after COVID-19 infection: a retrospective study.BMC cardiovascular disorders · 2024Article
- Assessing the Risk of QT Prolongation in a Psychiatric Inpatient Cohort: A Retrospective Cross-Sectional Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Prevalence, Outcomes, and Predictors of Prolonged Corrected QT Interval in Hydroxychloroquine-Naïve Hospitalized COVID-19 Patients.Cardiovascular toxicology · 2024Article
- The QT interval in Parkinson's disease: a systematic review.Journal of geriatric cardiology : JGC · 2024Article
- Does IV fentanyl, frequently used in emergency departments, change QTBMC anesthesiology · 2024Observational
- A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the effect of age on the ECG QT interval, an important predictor of cardiovascular mortality and drug-induced cardiac arrhythmias, and determine whether QT-heart rate correction formulae (QTc) have differential relationships with age and sex.
methodsData were examined from the US National Health and Nutrition Examination Survey (NHANES) II and III, civilian population aged 25 to 90 years. QT weighted means and standard deviations were calculated for all ages. The QTc were evaluated for six QTc: proposed by Bazett (QTcBZT), Fridericia (QTcFRD), Hodges (QTcHDG), Dmitrienko (QTcDMT), Rautaharju (QTcRTHa) and Framingham (QTcFRM).
resultsQTc was strongly related to age and gender, for all formulae except for QTcBZT for women. The relationship between QTc and age was significant regardless of whether the relationship was approximated by a linear or non-linear (quadratic or cubic spline) model. QTc increased more dramatically with age in men. There was a significant (
conclusionQTc and its variance increase with age. Prolonged QTc is more prevalent in older individuals, especially men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.