ReviewFrontiers in microbiology2016
Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles.
Review in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 621 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
621 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,995 citations in OpenAlex.
- Antimicrobial efficacy and bonding properties of orthodontic bonding systems enhanced with silver nanoparticles: a systematic review with meta-analysis.BMC oral health · 2024Pooled it
- Review
- Single-phase silver nanoparticles from white tea: colloidal quality, mass-specific potency and bacterial envelope permeabilisation.RSC advances · 2026Article
- Clinical translation and landscape of copper nanoparticles.Drug delivery and translational research · 2026Review
- Green-synthesized silver nanoparticles from fresh and wasteRSC advances · 2026Article
- Biocomposite Microparticles Incorporating Ibuprofen and ZnO Nanoparticles for Controlled Drug Delivery and Antimicrobial Therapy.Polymers · 2026Article
- Biocompatibility and Multifunctional Biological Evaluation of Flower-Shaped Ag₂CO₃ and Ag/Ag₂CO₃ Nanostructures in Diabetic Albino Mice.Applied biochemistry and biotechnology · 2026Article
- Green Synthesis of Silver Nanoparticles fromMolecules (Basel, Switzerland) · 2026Article
- Review
- Biologically Mediated Nanoparticle Synthesis as a Potential Green Strategy: Principles, Methods, and Pharmaceutical Applications.Pharmaceutics · 2026Review
- Influence of thermal treatment on the physicochemical, biological, and ecotoxicological properties of plant-mediated metal and metal-oxide nanoparticles.Scientific reports · 2026Article
- Green Synthesis of Silver Nanoparticles From Various Leaves Extract: Antioxidant, Anti-Inflammatory, Antibacterial Activities and Inhibitory Effect on Glutathione S-Transferase.Food science & nutrition · 2026Article
- Seasonal assessment of groundwater quality and irrigation suitability using a solar-powered AgNP/activated carbon treatment system in a coastal aquifer.Scientific reports · 2026Article
- Exploitation of Nanoparticle-Essential Oil Combinations to Enhance the Efficacy of Antimicrobial Agents AgainstPharmaceutics · 2026Article
- Covalently Immobilized Lignin-Xanthene Conjugates for Persistent Surface Photochemistry and Self-Sterilizing Interfaces Under Ambient Visible Light.Macromolecular rapid communications · 2026Article
- Applications of Bioinorganic Nano-Based Delivery Systems-Diagnostics and Therapeutics.Drug development research · 2026Review
- [Oral mucosal administration].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Article
- Green solution-plasma synthesis of GO-Ag nanocomposites for ultrasensitive SERS detection of rhodamine B and synergistic antibacterial activity.RSC advances · 2026Article
- Silver-Doped Mesoporous Calcium Phosphate for Controlled Amoxicillin Delivery and Modulation of Osteoblast-like Cell Response.Pharmaceutics · 2026Article
- Bioactive Silver Nanoparticles Synthesized Using EndophyticPharmaceuticals (Basel, Switzerland) · 2026Article
561 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug resistance of the pathogenic microorganisms to the antimicrobial drugs has become a major impediment toward successful diagnosis and management of infectious diseases. Recent advancements in nanotechnology-based medicines have opened new horizons for combating multidrug resistance in microorganisms. In particular, the use of silver nanoparticles (AgNPs) as a potent antibacterial agent has received much attention. The most critical physico-chemical parameters that affect the antimicrobial potential of AgNPs include size, shape, surface charge, concentration and colloidal state. AgNPs exhibits their antimicrobial potential through multifaceted mechanisms. AgNPs adhesion to microbial cells, penetration inside the cells, ROS and free radical generation, and modulation of microbial signal transduction pathways have been recognized as the most prominent modes of antimicrobial action. On the other side, AgNPs exposure to human cells induces cytotoxicity, genotoxicity, and inflammatory response in human cells in a cell-type dependent manner. This has raised concerns regarding use of AgNPs in therapeutics and drug delivery. We have summarized the emerging endeavors that address current challenges in relation to safe use of AgNPs in therapeutics and drug delivery platforms. Based on research done so far, we believe that AgNPs can be engineered so as to increase their efficacy, stability, specificity, biosafety and biocompatibility. In this regard, three perspectives research directions have been suggested that include (1) synthesizing AgNPs with controlled physico-chemical properties, (2) examining microbial development of resistance toward AgNPs, and (3) ascertaining the susceptibility of cytoxicity, genotoxicity, and inflammatory response to human cells upon AgNPs exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.