Evidence map›Paper›PMID 27899901›Full record

ArticleFrontiers in psychiatry2016

Association of Aryl Hydrocarbon Receptor-Related Gene Variants with the Severity of Autism Spectrum Disorders.

Takashi X Fujisawa, Shota Nishitani, Ryoichiro Iwanaga, Junko Matsuzaki, Chisato Kawasaki, Mamoru Tochigi, Tsukasa Sasaki, Nobumasa Kato, Kazuyuki Shinohara

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  12. The role of the microbiota-gut-brain axis in neuropsychiatric disorders.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Takashi X FujisawaDepartment of Neurobiology and Behavior, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
Shota NishitaniDepartment of Neurobiology and Behavior, Graduate School of Biomedical Sciences, Nagasaki University , Nagasaki , Japan.
Ryoichiro IwanagaDepartment of Occupational Therapy, Graduate School of Health Sciences, Nagasaki University , Nagasaki , Japan.
Junko MatsuzakiNagasaki Municipal Welfare Center for the Handicapped , Nagasaki , Japan.
Chisato KawasakiSasebo Child Development Center , Sasebo , Japan.
Mamoru TochigiDepartment of Neuropsychiatry, Teikyo University School of Medicine , Tokyo , Japan.
Tsukasa SasakiDepartment of Physical and Health Education, Graduate School of Education, The University of Tokyo , Tokyo , Japan.
Nobumasa KatoMedical Institute of Developmental Disabilities Research, Showa University , Tokyo , Japan.
Kazuyuki ShinoharaDepartment of Neurobiology and Behavior, Graduate School of Biomedical Sciences, Nagasaki University , Nagasaki , Japan.
Nagasaki University · JPJapan Graduate School of Education University · JPNagasaki Municipal Hospital · JPSasebo City General Hospital · JPShowa University · JPTeikyo University · JPUniversity of Fukui · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to environmental chemicals, such as dioxin, is known to have adverse effects on the homeostasis of gonadal steroids, thereby potentially altering the sexual differentiation of the brain to express autistic traits. Dioxin-like chemicals act on the aryl hydrocarbon receptor (AhR), polymorphisms, and mutations of

Indexed as

aryl hydrocarbon receptoraryl hydrocarbon receptor nuclear translocatorautism spectrum disorderpolymorphismseveritysocial communication

Identifiers

PMID27899901
PMCPMC5110561
OpenAlexW2554254959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.