ReviewFrontiers in physiology2016
Cellular and Molecular Responses to Mechanical Expansion of Tissue.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Autologous Concentrated Growth Factor Increases Skin Thickness and Area during Tissue Expansion: A Randomized Clinical Trial.Plastic and reconstructive surgery · 2023Trial
- Hydrogel soft tissue expander for gingiva-periosteal expansion: a narrative literature review.Maxillofacial plastic and reconstructive surgery · 2026Review
- The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth.Nature communications · 2025Article
- Application of rebound tonometer on skin surface pressure measurement: a pilot proof of concept study.Frontiers in bioengineering and biotechnology · 2025Article
- Gingivo-Periosteal Expansion of Edentulous Jaw Crest with An Osmotic Self-Inflatable Expander: A Preclinical in Vivo Study.The Journal of craniofacial surgery · 2024Article
- Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.Burns & trauma · 2024Article
- Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor.Experimental dermatology · 2023Article
- The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration.Biomolecules · 2023Review
- Effects of mechanical forces on the formation of cutaneous wounds during skin expansion and emerging therapies for wound healing and scar prevention.Saudi medical journal · 2023Article
- S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion.Burns & trauma · 2023Article
- The Alleviating Effect ofMolecules (Basel, Switzerland) · 2022Article
- Bayesian calibration of a computational model of tissue expansion based on a porcine animal model.Acta biomaterialia · 2022Article
- Utility of a Continuous External Tissue Expander in Complex Pediatric Wound Reconstruction.Eplasty · 2022Article
- Mechanical strain induces ex vivo expansion of periosteum.PloS one · 2022Article
- Identification of Common Hub Genes in Human Dermal Fibroblasts Stimulated by Mechanical Stretch at Both the Early and Late Stages.Frontiers in surgery · 2022Article
- Impact of Breast Reconstruction on Biophysical Parameters of Mammary Skin in Patients Receiving Postmastectomy Radiotherapy for Breast Cancer.Journal of breast cancer · 2021Article
- Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch.Frontiers in genetics · 2021Article
- The Use of Self-Inflating Hygroscopic Tissue Expanders to Facilitate Osteosarcoma Removal in a Massasauga Rattlesnake (Case reports in veterinary medicine · 2020Article
- Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion.Tissue engineering. Part C, Methods · 2019Review
- Macrophages are necessary for skin regeneration during tissue expansion.Journal of translational medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increased use of tissue expander in the past decades and its potential market values in near future give enough reasons to sum up the consequences of tissue expansion. Furthermore, the patients have the right to know underlying mechanisms of adaptation of inserted biomimetic, its bioinspired materials and probable complications. The mechanical strains during tissue expansion are related to several biological phenomena. Tissue remodeling during the expansion is highly regulated and depends on the signal transduction. Any alteration may lead to tumor formation, necrosis and/or apoptosis. In this review, stretch induced cell proliferation, apoptosis, the roles of growth factors, stretch induced ion channels, and roles of second messengers are organized. It is expected that readers from any background can understand and make a decision about tissue expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.