ReviewFrontiers in physiology2016
Moderate Load Eccentric Exercise; A Distinct Novel Training Modality.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Eccentric and Concentric Cycling Exercise Regimens on Hemodynamic and Hemorheologic Properties in Sedentary Male
Exploring Long-Term Benefits of Eccentric Cycling Exercise on Physiological Responses, Exercise Capacity, and Quality of Life in Patients With Type 2 Diabetes Mellitus
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Chronic Adaptations to Eccentric Cycling Training: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Effect of Cycling Cadence on Neuromuscular Function: A Systematic Review of Acute and Chronic Alterations.International journal of environmental research and public health · 2021Pooled it
- Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019Pooled it
- Cadence effects on cardiorespiratory and muscular responses during eccentric cycling.European journal of applied physiology · 2026Trial
- Effects of basic and dual-task training programs on physical function in Parkinson's disease: The PARKEX study.PloS one · 2026Trial
- Effects of once- versus twice-weekly eccentric resistance training on muscular function and structure in older adults: a randomised controlled trial.Scientific reports · 2024Trial
- Transcriptomic adaptation during skeletal muscle habituation to eccentric or concentric exercise training.Scientific reports · 2021Trial
- Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.GeroScience · 2021Trial
- Effects of Eccentric Single-Leg Decline Squat Exercise on the Morphological and Structural Properties of the Vastus Lateralis and Patellar Tendon.International journal of environmental research and public health · 2020Trial
- Eccentric Cycling Training Improves Health-Related Quality of Life in Adolescents with Obesity.Obesity facts · 2020Trial
- Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity.Scandinavian journal of medicine & science in sports · 2019Trial
- Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program.BMC geriatrics · 2017Trial
- Eccentric cycling for chronic respiratory disease: Does helmet ventilation add value? A randomized controlled trial.Chronic respiratory diseaseTrial
- Photobiomodulation versus ischemic preconditioning for protection against exercise-induced muscle damage: protocol for a randomized controlled trial.Lasers in medical science · 2026Article
- Effects of chemical myosin II cross-bridge inhibitors on eccentric force production in skinned muscle fibres.Experimental physiology · 2026Article
- Partial bodyweight-supported squats elicit eccentric contraction of the thigh muscles.BMC musculoskeletal disorders · 2026Article
- Maximal eccentric-concentric strength determines stretch-shortening cycle leg power across biological sexes.Scientific reports · 2026Article
- Activity-dependent remodeling of muscle architecture during distinct locomotor behaviors in Caenorhabditis elegans.Biology open · 2026Article
- Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.Journal of cachexia, sarcopenia and muscle · 2025Article
- Acute effects of supramaximal loaded back squat activation on countermovement jump performance, muscle mechanical properties, and skin surface temperature in powerlifters.European journal of sport science · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min. This type of training has been characterizes as moderate load eccentric exercise. It has also been denoted RENEW (Resistance Exercise via Negative Eccentric Work by LaStayo et al., 2014). It is distinct from plyometric exercises (i.e., drop jumps) that impose muscle loads of several thousand Watts on muscles and tendons. It is also distinct from eccentric overload training whereby loads in a conventional strength training setting are increased in the eccentric phase of the movement to match concentric loads. Moderate load eccentric exercise (or RENEW) has been shown to be similarly effective as conventional strength training in increasing muscle strength and muscle volume. However, as carried out at higher angular velocities of joint movement, it reduces joint loads. A hallmark of moderate load eccentric exercise is the fact that the energy requirements are typically 4-fold smaller than in concentric exercise of the same load. This makes moderate load eccentric exercise training the tool of choice in medical conditions with limitations in muscle energy supply. The use and effectiveness of moderate load eccentric exercise has been demonstrated mostly in small scale studies for cardiorespiratory conditions, sarcopenia of old age, cancer, diabetes type 2, and neurological conditions. It has also been used effectively in the prevention and rehabilitation of injuries of the locomotor system in particular the rehabilitation after anterior cruciate ligament surgery.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.