ArticleNucleic acids research2017
InterPro in 2017-beyond protein family and domain annotations.
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Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 845 papers.
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845citing papers in PubMed
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845 citing papers in PubMed.
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785 more citing papers are in PubMed but not listed here.
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Authors and funding
47 authors.
Robert D FinnEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK rdf@ebi.ac.uk.
Teresa K AttwoodSchool of Computer Science, University of Manchester, UK.
Patricia C BabbittDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
Alex BatemanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0002-6982-4660
Peer BorkEuropean Molecular Biology Laboratory, Biocomputing, Meyerhofstasse 1, 69117 Heidelberg, Germany.
Alan J BridgeSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Hsin-Yu ChangEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Zsuzsanna DosztányiMTA-ELTE Lendület Bioinformatics Research Group, Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest, Hungary.
Sara El-GebaliEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Matthew FraserEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Julian GoughComputer Science department, University of Bristol, Woodland Road, Bristol BS8 1UB, UK.
David HaftBioinformatics Department, J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA.
Gemma L HollidayDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-6731-6398
Hongzhan HuangCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
Xiaosong HuangDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Ivica LetunicBiobyte Solutions GmbH, Bothestr. 142, 69126 Heidelberg, Germany.
Rodrigo LopezEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Shennan LuNational Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Aron Marchler-BauerNational Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Huaiyu MiDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jaina MistryEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Darren A NataleGeorgetown University Medical Center, 3300 Whitehaven St, NW, Washington, DC 20007, USA.
Marco NecciDepartment of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
Gift NukaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Christine A OrengoStructural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
Youngmi ParkEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Sebastien PesseatEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Damiano PiovesanDepartment of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
Simon C PotterEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Neil D RawlingsEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Nicole RedaschiSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Lorna RichardsonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Catherine RivoireSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Amaia Sangrador-VegasEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Christian SigristSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Ian SillitoeStructural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
Ben SmithersComputer Science department, University of Bristol, Woodland Road, Bristol BS8 1UB, UK.ORCID 0000-0001-9508-8065
Silvano SquizzatoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Granger SuttonBioinformatics Department, J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA.
Narmada ThankiNational Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Paul D ThomasDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Silvio C E TosattoDepartment of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.ORCID 0000-0003-4525-7793
Cathy H WuCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
Ioannis XenariosSwiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Lai-Su YehGeorgetown University Medical Center, 3300 Whitehaven St, NW, Washington, DC 20007, USA.
Siew-Yit YoungEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Alex L MitchellEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Funding
Laying the Foundation of Genomic EnzymologyR01GM060595 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BABBITT, PATRICIA CLEMENT · 2000 to 2018
$5.4MBiotechnology and Biological Sciences Research Council BB/L024136/1Biotechnology and Biological Sciences Research Council BB/N00521X/1NIGMS NIH HHS R01 GM060595Wellcome Trust 108433/Z/15/Z
Abstract
InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.
Indexed as
Databases, ProteinProtein Interaction Domains and MotifsSoftwareComputational BiologyHumansMolecular Sequence AnnotationPhylogeny
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