Evidence map›Paper›PMID 27899604›Full record

ArticleNucleic acids research2017

IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex.

Giuseppe Maccari, James Robinson, Keith Ballingall, Lisbeth A Guethlein, Unni Grimholt, Jim Kaufman, Chak-Sum Ho, Natasja G de Groot, Paul Flicek, Ronald E Bontrop and 2 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  13. Baseline Characterization of Swine Leukocyte Antigen Diversity in GFP-Expressing Domestic Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giuseppe MaccariThe Pirbright Institute, Pirbright, Woking, Surrey, GU24 0NF, UK.
James RobinsonAnthony Nolan Research Institute (ANRI), Royal Free Hospital, London, NW3 2QG, UK.
Keith BallingallMoredun Research Institute, Pentlands Science Park, Midlothian, EH26 0PZ, UK.
Lisbeth A GuethleinStanford University, Stanford, CA, 94305, USA.
Unni GrimholtNorwegian Veterinary Institute, Oslo, 0454, Norway.
Jim KaufmanUniversity of Cambridge, Cambridge, CB2 1QP, UK.
Chak-Sum HoGift of Life Michigan, Ann Arbor, MI, 48108, USA.
Natasja G de GrootBiomedical Primate Research Centre, Rijswijk, 2288 GJ Rijswijk, Netherlands.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.ORCID 0000-0002-3897-7955
Ronald E BontropBiomedical Primate Research Centre, Rijswijk, 2288 GJ Rijswijk, Netherlands.
John A HammondThe Pirbright Institute, Pirbright, Woking, Surrey, GU24 0NF, UK.
Steven G E MarshAnthony Nolan Research Institute (ANRI), Royal Free Hospital, London, NW3 2QG, UK steven.marsh@ucl.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/M011488/1
6 · The paper itself

Abstract

The IPD-MHC Database project (http://www.ebi.ac.uk/ipd/mhc/) collects and expertly curates sequences of the major histocompatibility complex from non-human species and provides the infrastructure and tools to enable accurate analysis. Since the first release of the database in 2003, IPD-MHC has grown and currently hosts a number of specific sections, with more than 7000 alleles from 70 species, including non-human primates, canines, felines, equids, ovids, suids, bovins, salmonids and murids. These sequences are expertly curated and made publicly available through an open access website. The IPD-MHC Database is a key resource in its field, and this has led to an average of 1500 unique visitors and more than 5000 viewed pages per month. As the database has grown in size and complexity, it has created a number of challenges in maintaining and organizing information, particularly the need to standardize nomenclature and taxonomic classification, while incorporating new allele submissions. Here, we describe the latest database release, the IPD-MHC 2.0 and discuss planned developments. This release incorporates sequence updates and new tools that enhance database queries and improve the submission procedure by utilizing common tools that are able to handle the varied requirements of each MHC-group.

Indexed as

Databases, GeneticAnimalsComputational BiologyMajor Histocompatibility ComplexSoftwareWeb Browser

Identifiers

PMID27899604
PMCPMC5210539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.