Evidence map›Paper›PMID 27899573›Full record

ArticleNucleic acids research2017

The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.

Ingrid M Keseler, Amanda Mackie, Alberto Santos-Zavaleta, Richard Billington, César Bonavides-Martínez, Ron Caspi, Carol Fulcher, Socorro Gama-Castro, Anamika Kothari, Markus Krummenacker and 11 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 322 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

322 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. ACS synthetic biology · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Genomes of NBMC genomics · 2026
    Article
  11. Article
  12. Article
  13. The EcoCyc database (2025).EcoSal Plus · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Improving NiInternational journal of molecular sciences · 2024
    Article

262 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ingrid M KeselerSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Amanda MackieDepartment of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia.
Alberto Santos-ZavaletaPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Richard BillingtonSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
César Bonavides-MartínezPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Ron CaspiSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Carol FulcherSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Socorro Gama-CastroPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Anamika KothariSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Markus KrummenackerSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Mario LatendresseSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Luis Muñiz-RascadoPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Quang OngSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Suzanne PaleySRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Martin Peralta-GilPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Pallavi SubhravetiSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
David A Velázquez-RamírezPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Daniel WeaverSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Julio Collado-VidesPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, A.P. 565-A, Cuernavaca, Morelos 62100, Mexico.
Ian PaulsenDepartment of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia.
Peter D KarpSRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA pkarp@ai.sri.com.

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
HIGH THROUGHPUT LITERATURE CURATION OF GENETIC REGULATION IN BACTERIAL MODELSR01GM110597 · NIGMS · CENTER FOR GENOMIC SCIENCES · PI COLLADO-VIDES, JULIO · 2015 to 2018
$1.6M
NIGMS NIH HHS R01 GM110597NIGMS NIH HHS U24 GM077678
6 · The paper itself

Abstract

EcoCyc (EcoCyc.org) is a freely accessible, comprehensive database that collects and summarizes experimental data for Escherichia coli K-12, the best-studied bacterial model organism. New experimental discoveries about gene products, their function and regulation, new metabolic pathways, enzymes and cofactors are regularly added to EcoCyc. New SmartTable tools allow users to browse collections of related EcoCyc content. SmartTables can also serve as repositories for user- or curator-generated lists. EcoCyc now supports running and modifying E. coli metabolic models directly on the EcoCyc website.

Indexed as

Databases, GeneticComputational BiologyEnergy MetabolismEscherichia coli K12Escherichia coli ProteinsGene Expression Regulation, BacterialMetabolic Networks and PathwaysSignal TransductionSoftwareTranscription FactorsWeb BrowserEscherichia coli ProteinsTranscription Factors

Identifiers

PMID27899573
PMCPMC5210515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.