ArticleMolecular cancer research : MCR2017
High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV.
Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Human papillomavirus-related oral lesions in people with HIV: A 20-year multinational cohort analysis.Journal of dental sciences · 2026Article
- Impact of HIV status on overall survival in head and neck cancers by anatomical site and stage: A multi-center cohort study.Oral oncology · 2025Article
- Oral HPV incidence and risk factors for acquisition.Oral oncology · 2025Observational
- Human Immunodeficiency Virus Is Associated With Poor Overall Survival Among Patients With Head and Neck Cancer.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Exploiting the Molecular Basis of Oesophageal Cancer for Targeted Therapies and Biomarkers for Drug Response: Guiding Clinical Decision-Making.Biomedicines · 2022Review
- Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults.Tumour virus research · 2022Article
- Impact of human immunodeficiency virus status on laryngeal cancer survival and locoregional control.Laryngoscope investigative otolaryngology · 2022Article
- Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [Pharmaceutical biology · 2021Article
- Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Article
- Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana.Health science reports · 2019Article
- Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma.Cancer management and research · 2019Review
- Head and neck squamous cell carcinoma and its correlation with human papillomavirus in people living with HIV: a systematic review.Oncotarget · 2018Review
- HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers.Oral oncology · 2018Article
- Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.Cancer · 2018Article
- Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma.Head & neck · 2017Article
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12 authors at 7 institutions in 1 country.
Funding
Abstract
In this study, high-risk HPV (hrHPV) incidence, prognostic biomarkers, and outcome were assessed in HIV-positive (case) and HIV-negative (control) patients with head and neck squamous cell cancer (HNSCC). HIV-positive cases were matched to controls by tumor site, sex, and age at cancer diagnosis. A tissue microarray (TMA) was constructed and DNA isolated from tumor tissue. MultiPlex-PCR MassArray, L1-PCR, and in situ hybridization were used to assess hrHPV. TMA sections were stained for p16ink4a, TP53, RB, CCND1, EGFR, and scored for intensity and proportion of positive tumor cells. The HNSCC cohort included 41 HIV-positive cases and 41 HIV-negative controls. Tumors from 11 of 40 (28%) cases, and 10 of 41 (24%) controls contained hrHPV. p16 expression, indicative of E7 oncogene activity, was present in 10 of 11 HPV-positive cases and 7 of 10 HPV-positive controls. Low p16 and high TP53 expression in some HPV-positive tumors suggested HPV-independent tumorigenesis. Survival did not differ in cases and controls. RB expression was significantly associated with poor survival (P = 0.01). High TP53 expression exhibited a trend for poorer survival (P = 0.12), but among cases, association with poor survival reached statistical significance (P = 0.04). The proportion of HPV-positive tumors was similar, but the heterogeneity of HPV types was higher in the HIV-positive cases than in HIV-negative controls. High RB expression predicted poor survival, and high TP53 expression was associated with poorer survival in the HIV-positive cases but not HIV-negative controls. IMPLICATIONS: HIV infection did not increase risk of death from HNSCC, and HPV-positive tumors continued to be associated with a significantly improved survival, independent of HIV status. Mol Cancer Res; 15(2); 179-88. ©2016 AACR.
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