ReviewItalian journal of pediatrics2016
Physiopathology of vesico-ureteral reflux.
Review in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- A prospective randomized trial comparing the effects of anti-reflux versus standard ureteral stents on male sexual function.Scientific reports · 2026Trial
- Etiological Spectrum and Anatomical Locations of Hydronephrosis in Western Region of Yemen.Pakistan journal of medical sciences · 2025Article
- A Comparison of Contrast-Enhanced Voiding Urosonography (CE-VUS) and Contrast Retrograde Cystourethrography (RCUG) for the Detection of Vesicoureteral Reflux in Young Dogs.Animals : an open access journal from MDPI · 2025Article
- Urinary bladder transplantation in humans - current status and future perspectives.Nature reviews. Urology · 2025Review
- Clinical characteristics of primary vesicoureteral reflux in children with an allergic constitution.European journal of medical research · 2024Article
- Primary vesicoureteral reflux.Nature reviews. Disease primers · 2024Review
- Ultrasound-based predictive indicators for treatment outcomes in pediatric vesicoureteral reflux.Surgery today · 2024Article
- Congenital anomalies of the kidney and urinary tract.Frontiers in medicine · 2024Review
- An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle.The Journal of physiology · 2023Article
- Incidence and predictive factors for developing vesicoureteric reflux in individuals with suprasarcral spinal cord injury: a historical cohort study.Spinal cord · 2021Article
- Evaluation of the Diagnostic Value of Contrast-Enhanced Voiding Urosonography with Regard to the Further Therapy Regime and Patient Outcome-A Single-Center Experience in an Interdisciplinary Uroradiological Setting.Medicina (Kaunas, Lithuania) · 2021Article
- Association of vesicoureteral reflux and gastroesophageal reflux disease in children: A population-based study.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- The ABCs of Voiding Cystourethrography.Taehan Yongsang Uihakhoe chi · 2020Review
- Ureterovesical Junction and Waldeyer's Sheath: A Narrative Review Applied to Vesicoureteral Reflux.International braz j urol : official journal of the Brazilian Society of UrologyReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vescico-Ureteral Reflux (VUR) is a common condition in childhood, caused by a congenital anomaly at the Vescico-Ureteral Junction (VUJ) level. It seems that the main cause could be an abnormal embryological development occurred during the early stage of fetal life.Refluxing ureteral endings show structural and functional anomalies: previous studies have shown a significant decrease in alfa actin, miosin and desmin contents as well as an high rate of atrophy and muscular degeneration with disorganized muscular fibres. The roles played by Cajal cells and Connexin 43 in generating peristaltic waves appears to be fundamental for the physiological VUJ function and activity. Attention was focused also on the congenital muscular deficiency of the RUs, on regard to general morphology, smooth muscle cells architecture, inflammatory markers and the distribution of collagen composition.This review will discuss and investigate the importance of the modified configuration of Sarcoglycan (SG) sub complex (particularly the deficiency of the ε-SG and the increased expression of the α-SG), the role played by Cajal Cells, the intravescical tunnel length to ureteral diameter ratio as possible causes of the functional alterations in the refluxing ureteral ends leading towards the VUJ incompetence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.