ArticleBMC pharmacology & toxicology2016
Vancomycin microspheres reduce postoperative spine infection in an in vivo rabbit model.
Article in BMC pharmacology & toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Impact of implant metal type and vancomycin prophylaxis on postoperative spine infection: an in-vivo study.Spine deformity · 2023Article
- Epidemiology of postoperative spinal wound infection in the Middle East and North Africa (MENA) region.North American Spine Society journal · 2023Article
- Animal Models for Postoperative Implant-Related Spinal Infection.Orthopaedic surgery · 2022Review
- Role of Animal Models to Advance Research of Bacterial Osteomyelitis.Frontiers in veterinary science · 2022Review
- Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design.JOR spine · 2021Review
- A Novel Strategy to Coat Dopamine-Functionalized Titanium Surfaces With Agarose-Based Hydrogels for the Controlled Release of Gentamicin.Frontiers in cellular and infection microbiology · 2021Article
- Postoperative Spine Infection: Diagnosis and Management.Global spine journal · 2018Article
- Options and Limitations in Clinical Investigation of Bacterial Biofilms.Clinical microbiology reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical site infections are common and devastating complications after implants related surgeries. Staphylococcus aureus contamination is a leading cause of surgical site infections. This study aims at assessing the effect of vancomycin microspheres on reducing Staphylococcus aureus infection in an in vivo rabbit model.
methodsSixty surgical sites of 20 New Zealand White rabbits underwent spinal implant were randomly divided to three groups: the control group, the vancomycin group and vancomycin microspheres group. The surgical sites were incubated with 100 μl 1 × 10
resultsAll the rabbits survived the surgery and no postoperative wound complications or systemic illness occurred. Results showed that the bacterial cultures were 76.9, 30.8, and 15.4% in the control group, vancomycin group, and vancomycin microspheres group. Vancomycin microspheres treatments significantly decreased the infection rate compared to the control group (p < 0.05).
conclusionVancomycin microspheres combined with preoperative ceftriaxone is effective to reduce postoperative S. aureus infection compared with the control group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.