ArticleBMC ophthalmology2016
Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal.
Article in BMC ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 46 citations in OpenAlex.
- Village-integrated eye workers for prevention of corneal ulcers in Nepal (VIEW study): a cluster-randomised controlled trial.The Lancet. Global health · 2022Trial
- Therapeutic Potential of Desert Truffles in the Management of Eye Infections: Demystifying the Fact.Combinatorial chemistry & high throughput screening · 2026Review
- Causative Agents of Fungal Keratitis in Northeastern Iran: A 3-Year Tertiary Care Hospital Study.The American journal of tropical medicine and hygiene · 2025Article
- Resistance trend in bacteria isolated from corneal ulcers: A retrospective analysis from Pakistan.PloS one · 2025Article
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- Real-life experience on the effectiveness of conjunctival flap and amniotic membrane graft in the treatment of refractory fungal corneal ulcer.Japanese journal of ophthalmology · 2024Observational
- Article
- Microbiological Profile in Patients Having Keratitis in a Tertiary Care Hospital in India.Cureus · 2022Article
- Clinical characteristics of external bacterial ocular and periocular infections and their antimicrobial treatment patterns among a Ghanaian ophthalmic population.Scientific reports · 2022Article
- Microbial Keratitis in Nepal: Predicting the Microbial Aetiology from Clinical Features.Journal of fungi (Basel, Switzerland) · 2022Article
- Mycoplasma infection and ocular surface diseases: a nationwide cohort study.Scientific reports · 2021Observational
- Epidemiology of keratitis/scleritis-related endophthalmitis in a university hospital in Thailand.Scientific reports · 2021Article
- Mycotic Keratitis-A Global Threat from the Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Etiological spectrum of infectious keratitis in the era of MALDI-TOF-MS at a tertiary care hospital.Journal of family medicine and primary care · 2020Article
- Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study.Neuropsychiatric disease and treatment · 2020Article
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- Article
- Microbiological Profile of Corneal Ulcers at a Tertiary Referral Center.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Article
- Ten-year analysis of microbiological profile and antibiotic sensitivity for bacterial keratitis in Korea.PloS one · 2019Article
- Pattern of corneal disorders in Ekiti: A tertiary eye center experience.Annals of African medicineArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCorneal ulcer, a major cause of monocular blindness in developing countries has consistently been listed as the major cause of blindness and visual disability in many of the developing nations in Asia, Africa and the Middle East, ranking second only to cataract. This study was carried out to determine the microbiological profile of corneal ulcer cases diagnosed among patients visiting Tilganga Institute of Ophthalmology (TIO), Nepal.
methodsA total of 101 corneal scrapping samples were tested for routine culture and antibiotic susceptibility at the pathology department of TIO Nepal from April to October 2014. Microorganisms were identified by using standard microbiological procedures following the manual of American Society for Microbiology (ASM) and their antibiotic susceptibility test, performed by Kirby-Bauer disc diffusion method in conformity with the CLSI guideline.
resultsOut of 101 samples analyzed, 44.6% (45/101) showed positive growth with bacterial isolates i.e., 56% (25/45), more prevalent than fungus i.e., 44% (20/45). Among bacteria Streptococcus pneumoniae (31.1%, N = 14) was isolated in highest number whereas Fusarium (13.4%, N = 6) was the most common fungus species. Pseudomonas aeruginosa was the only Gram negative bacteria isolated from corneal ulcer cases. All bacterial isolates were found to be susceptible to the quinolone group of antibiotics (moxifloxacin followed by ofloxacin and ciprofloxacin).
conclusionsThese findings showcase the current trend in the microbiological etiology of corneal ulcer in Nepal, which have important public health implications for the treatment as well as prevention of corneal ulceration in the developing world.
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