Evidence map›Paper›PMID 27899082›Full record

SynthesisBMC pediatrics2016

Interventions to improve gross motor performance in children with neurodevelopmental disorders: a meta-analysis.

Barbara R Lucas, Elizabeth J Elliott, Sarah Coggan, Rafael Z Pinto, Tracy Jirikowic, Sarah Westcott McCoy, Jane Latimer

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05340049 (Early Craniosacral Therapy Improves Infant Neurodevelopment in Apparently Healthy Children.), which is not on this map. Cited by 43 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 7 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05340049 nacompletednot on this mapstarted 2021, after this paper: background citation

Early Craniosacral Therapy Improves Infant Neurodevelopment in Apparently Healthy Children.

TypeinterventionalSponsorClinica Gema LeonRan2021 to 2022Enrolled120ConditionsChild Development DisorderArmsAcademic behavioral intervention of teachers, Therapy sessions
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Barbara R LucasDiscipline of Paediatrics and Child Health, The University of Sydney, The Children's Hospital at Westmead, Clinical School, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia. blucas@georgeinstitute.org.au.
Elizabeth J ElliottDiscipline of Paediatrics and Child Health, The University of Sydney, The Children's Hospital at Westmead, Clinical School, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia.
Sarah CogganThe George Institute for Global Health, Sydney Medical School, University of Sydney, PO Box M201, , Missenden Rd, Sydney, NSW, 2050, Australia.
Rafael Z PintoPain Management Research Institute, University of Sydney at Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia.
Tracy JirikowicDivision of Occupational Therapy, Department of Rehabilitation Medicine, University of Washington, Seattle, WA, 98195, USA.
Sarah Westcott McCoyDivision of Physical Therapy, Department of Rehabilitation Medicine, University of Washington, Seattle, WA, 98195, USA.
Jane LatimerThe George Institute for Global Health, Sydney Medical School, University of Sydney, PO Box M201, , Missenden Rd, Sydney, NSW, 2050, Australia.
University of Sydney · AUThe George Institute for Global Health · AUUniversity of Washington · US

Funding

Sensorimotor Training to Affect Balance, Engagement and Learning in Children withR33AA019579 · NIAAA · UNIVERSITY OF WASHINGTON · PI JIRIKOWIC, TRACY L · 2011 to 2013
$652k
Sensorimotor Training to Affect Balance, Engagement and Learning in Children withR21AA019579 · NIAAA · UNIVERSITY OF WASHINGTON · PI JIRIKOWIC, TRACY L, MCCOY, SARAH WESTCOTT · 2009 to 2010
$408k
NIAAA NIH HHS R21 AA019579NIAAA NIH HHS R33 AA019579
6 · The paper itself

Abstract

backgroundGross motor skills are fundamental to childhood development. The effectiveness of current physical therapy options for children with mild to moderate gross motor disorders is unknown. The aim of this study was to systematically review the literature to investigate the effectiveness of conservative interventions to improve gross motor performance in children with a range of neurodevelopmental disorders.

methodsA systematic review with meta-analysis was conducted. MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, PEDro, Cochrane Collaboration, Google Scholar databases and clinical trial registries were searched. Published randomised controlled trials including children 3 to ≤18 years with (i) Developmental Coordination Disorder (DCD) or Cerebral Palsy (CP) (Gross Motor Function Classification System Level 1) or Developmental Delay or Minimal Acquired Brain Injury or Prematurity (<30 weeks gestational age) or Fetal Alcohol Spectrum Disorders; and (ii) receiving non-pharmacological or non-surgical interventions from a health professional and (iii) gross motor outcomes obtained using a standardised assessment tool. Meta-analysis was performed to determine the pooled effect of intervention on gross motor function. Methodological quality and strength of meta-analysis recommendations were evaluated using PEDro and the GRADE approach respectively.

resultsOf 2513 papers, 9 met inclusion criteria including children with CP (n = 2) or DCD (n = 7) receiving 11 different interventions. Only two of 9 trials showed an effect for treatment. Using the least conservative trial outcomes a large beneficial effect of intervention was shown (SMD:-0.8; 95% CI:-1.1 to -0.5) with "very low quality" GRADE ratings. Using the most conservative trial outcomes there is no treatment effect (SMD:-0.1; 95% CI:-0.3 to 0.2) with "low quality" GRADE ratings. Study limitations included the small number and poor quality of the available trials.

conclusionAlthough we found that some interventions with a task-orientated framework can improve gross motor outcomes in children with DCD or CP, these findings are limited by the very low quality of the available evidence. High quality intervention trials are urgently needed.

Indexed as

Motor SkillsPhysical Therapy ModalitiesBrain InjuriesCerebral PalsyChildDevelopmental DisabilitiesFetal Alcohol Spectrum DisordersHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesMotor Skills DisordersTreatment OutcomeCerebral palsyChild developmentDevelopmental Coordination DisorderMotor skillsMotor skills disordersNeurodevelopmental disordersPhysiotherapy

Identifiers

PMID27899082
PMCPMC5129231
OpenAlexW2558035719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.