Evidence map›Paper›PMID 27899077›Full record

ArticleBMC cancer2016

Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study.

Evangelia Pavlidou, Alexandros Daponte, Raquel Egea, Efthimios Dardiotis, Georgios M Hadjigeorgiou, Antonio Barbadilla, Theodoros Agorastos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Genetic variations in theOncology letters · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Evangelia PavlidouDepartment of Gynaecology and Obstetrics, Geneva University Hospitals , Geneva, Switzerland. pavlidou.evangelia@gmail.com.ORCID 0000-0002-7906-8977
Alexandros DaponteDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
Raquel EgeaInstitut de Biotecnologia i Biomedicina/Departament de Genètica i de Microbiologia, Universitat Autònoma Barcelona, 08192, Cerdanyola, Barcelona, Spain.
Efthimios DardiotisDepartment of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
Georgios M HadjigeorgiouDepartment of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
Antonio BarbadillaInstitut de Biotecnologia i Biomedicina/Departament de Genètica i de Microbiologia, Universitat Autònoma Barcelona, 08192, Cerdanyola, Barcelona, Spain.
Theodoros Agorastos4th University Clinic of Obstetrics and Gynecology, Aristotle University of Thessaloniki, "Hippokrateion" General Hospital of Thessaloniki, Thessaloniki, Greece.
University of Thessaly · GRAristotle University of Thessaloniki · GRUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the study was to evaluate the association of two SNPs of EVER1/2 genes' region (rs2290907, rs16970849) and the FAS-670 polymorphism with the susceptibility to precancerous lesions and cervical cancer in a Greek population.

methodsAmong the 515 women who were included in the statistical analysis, 113 belong to the case group and present with precancerous lesions or cervical cancer (27 with persistent CIN1, 66 with CIN2/3 and 20 with cervical cancer) and 402 belong to the control group. The chi-squared test was used to compare the case and the control groups with an allelic and a genotype-based analysis.

resultsThe results of the statistical analysis comparing the case and the control groups for all the SNPs tested were not statistically significant. Borderline significant difference (p value = 0.079) was only found by the allelic model between the control group and the CIN1/CIN2 patients' subgroup for the polymorphism rs16970849. The comparison of the other case subgroups with the control group did not show any statistically significant difference.

conclusionsNone of the SNPs included in the study can be associated with statistical significance with the development of precancerous lesions or cervical cancer.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAllelesCase-Control Studiesfas ReceptorFemaleGene FrequencyGenotypeGreeceHumansLinkage DisequilibriumMembrane ProteinsMiddle AgedNeoplasm StagingRiskfas ReceptorMembrane ProteinsTMC6 protein, humanTMC8 protein, humanCervical cancerEVERFASPolymorphism

Identifiers

PMID27899077
PMCPMC5129199
OpenAlexW2559380099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.