SynthesisPloS one2016
Biological Markers for Pulpal Inflammation: A Systematic Review.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 4 syntheses or guidelines pooled it, 216 citations in OpenAlex.
- Neural biomarkers in pulpitis and their associations with inflammation and pain perception: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- A systematic review and meta-analysis on the effects of phototherapy on postoperative pain in conventional endodontic reintervention.Clinical oral investigations · 2024Pooled it
- ILs and MMPs Levels in Inflamed Human Dental Pulp: A Systematic Review.Molecules (Basel, Switzerland) · 2021Pooled it
- Effects of 660 nm & 808 nm photo-biomodulation on S100A8/A9 in symptomatic pulpitis: a randomized controlled trial.Lasers in medical science · 2026Trial
- The short-term postoperative pain and impact upon quality of life of pulpotomy and root canal treatment, in teeth with symptoms of irreversible pulpitis: A randomized controlled clinical trial.International endodontic journal · 2025Trial
- Trial
- An innate defense regulator peptide modulates the inflamed pulp microenvironment and promotes pulp repair.Bioactive materials · 2026Article
- From bioactivity to biofunctional restorative materials: reappraising terminology and evidence.Clinical oral investigations · 2026Review
- Redefining the Evolution of Pulpal Pathology: Inflammasomes as Central Integrative Hubs and Biological Switches Governing the Transition From Reversible to Irreversible Pulpal Inflammation Beyond Symptom-Based Classification.International endodontic journal · 2026Review
- Inflammation-Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF-κB Crosstalk.International endodontic journal · 2026Review
- Ultrasensitive multiplex salivary cytokine profiling reveals distinct immune signatures in dental caries.BDJ open · 2026Article
- Establishment of an MRI-Based Diagnostic Approach to Identify Critical Pulpal Inflammation Zones in a Rat Caries-Derived Pulpitis Model.International endodontic journal · 2026Article
- Association between calcitonin gene-related peptide and substance P in saliva and pulp according to anxiety levels in patients with dental pain: a cross-sectional study.BMC oral health · 2026Article
- Enhancing the Odontogenic Potential of Human Dental Pulp Stem Cells via Platelet-Rich Plasma Exosomes through Modulation of TGF-β1 and Dentin Sialophosphoprotein.European journal of dentistry · 2026Article
- Effect of the combination of Solanesol fromJournal of conservative dentistry and endodontics · 2026Article
- Postoperative Pain and Matrix Metalloproteinase-9 Pulpal Blood Level in Symptomatic Pulpitis of Mature Molars Treated with Biodentine and Portland Cement Full Pulpotomy: A Randomized Clinical Trial.Journal of clinical and experimental dentistry · 2026Review
- Consensus-Based Recommendations on Pulp Therapies in Primary and Permanent Teeth: IAPD Porto Forum.International journal of paediatric dentistry · 2026Article
- Endodontic Inflammatory Disease: Systemic Consequences.Advances in experimental medicine and biology · 2026Review
- Bioactivity and Regenerative Potential of Cannabidiol in Human Dental Pulp Stem Cells: A Scoping Review of In Vitro Studies.TheScientificWorldJournal · 2026Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivePulpitis is mainly caused by an opportunistic infection of the pulp space with commensal oral microorganisms. Depending on the state of inflammation, different treatment regimes are currently advocated. Predictable vital pulp therapy depends on accurate determination of the pulpal status that will allow repair to occur. The role of several players of the host response in pulpitis is well documented: cytokines, proteases, inflammatory mediators, growth factors, antimicrobial peptides and others contribute to pulpal defense mechanisms; these factors may serve as biomarkers that indicate the status of the pulp. Therefore, the aim of this systematic review was to evaluate the presence of biomarkers in pulpitis.
methodsThe electronic databases of MEDLINE, EMBASE, Scopus and other sources were searched for English and non-English articles published through February 2015. Two independent reviewers extracted information regarding study design, tissue or analyte used, outcome measures, results and conclusions for each article. The quality of the included studies was assessed using a modification of the Newcastle-Ottawa-Scale. RESULTS AND
conclusionsFrom the initial 847 publications evaluated, a total of 57 articles were included in this review. In general, irreversible pulpitis was associated with different expression of various biomarkers compared to normal controls. These biomarkers were significantly expressed not only in pulp tissue, but also in gingival crevicular fluid that can be collected non-invasively, and in dentin fluid that can be analyzed without extirpating the entire pulpal tissue. Such data may then be used to accurately differentiate diseased from healthy pulp tissue. The interplay of pulpal biomarkers and their potential use for a more accurate and biologically based diagnostic tool in endodontics is envisaged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.