ArticlePloS one2016
Dietary Butyrate Helps to Restore the Intestinal Status of a Marine Teleost (Sparus aurata) Fed Extreme Diets Low in Fish Meal and Fish Oil.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 142 citations in OpenAlex.
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- Postbiotics and Paraprobiotics as Next-Generation Gut Microbiome Modulators in Sustainable Aquaculture Health.Antibiotics (Basel, Switzerland) · 2026Review
- Evaluating Sustainable Feed Alternatives inFoods (Basel, Switzerland) · 2026Article
- Effects of Tributyrin Supplementation in High-Soybean-Meal Diet on Growth Performance, Hemolymph and Hepatopancreas Immune and Antioxidant Parameters, and Intestinal Morphology of Juvenile Pacific White Shrimp (Animals : an open access journal from MDPI · 2026Article
- Postbiotic Dietary Supplementation with Sonicated Shewanella sp. SpPdp11 Improves Intestinal Status in Juvenile Senegalese Sole (Solea senegalensis).Marine biotechnology (New York, N.Y.) · 2026Article
- Assessment of low dietary inclusion of nutraceuticals derived from microalgae to enhance intestinal function in gilthead seabream (Sparus aurata) juveniles.Scientific reports · 2026Article
- From Brewery Waste to Sustainable Aquafeed: HarnessingAquaculture nutrition · 2026Article
- The Ghrelin Analog GHRP-6, Delivered Through Aquafeeds, Modulates the Endocrine and Immune Responses ofBiology · 2025Article
- Tryptophan-supplemented diet modulates the metabolic response of European seabass (Dicentrarchus labrax) juveniles reared under space-confined conditions and submitted to acute inflammation.Fish physiology and biochemistry · 2025Article
- Dietary Herbal Leaves Mixture Extract Enhances Growth, Antioxidant Status, and Resistance toAquaculture nutrition · 2025Article
- Insights into thermal sensitivity: Effects of elevated temperature on growth, metabolic rate, and stress responses in Atlantic wolffish (Anarhichas lupus).Journal of fish biology · 2025Article
- Effect of bile salts on intestinal epithelial function in gilthead seabream (Sparus aurata).Fish physiology and biochemistry · 2024Article
- Sustainable Fish Meal-Free Diets for Gilthead Sea Bream (Animals : an open access journal from MDPI · 2024Article
- Evaluation of Gamma Aminobutyric Acid and Sodium Butyrate in Juvenile Red Seabream (Animals : an open access journal from MDPI · 2024Article
- Study of the influence of tributyrin-supplemented diets on the gut bacterial communities of rainbow trout (Oncorhynchus mykiss).Scientific reports · 2024Article
- Dietary sodium acetate and sodium butyrate attenuate intestinal damage and improve lipid metabolism in juvenile largemouth bass (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- DietaryAquaculture nutrition · 2024Article
- The Application of Synthetic Flavors in Zebrafish (Animals : an open access journal from MDPI · 2023Article
- Soya saponins and prebiotics alter intestinal functions in Ballan wrasse (The British journal of nutrition · 2023Article
- Xylanase improves the intestinal barrier function of Nile tilapia (Oreochromis niloticus) fed with soybean (Glycine max) meal.Journal of animal science and biotechnology · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a constant need to find feed additives that improve health and nutrition of farmed fish and lessen the intestinal inflammation induced by plant-based ingredients. The objective of this study was to evaluate the effects of adding an organic acid salt to alleviate some of the detrimental effects of extreme plant-ingredient substitution of fish meal (FM) and fish oil (FO) in gilthead sea bream diet. Three experiments were conducted. In a first trial (T1), the best dose (0.4%) of sodium butyrate (BP-70 ®NOREL) was chosen after a short (9-weeks) feeding period. In a second longer trial (T2) (8 months), four diets were used: a control diet containing 25% FM (T2-D1) and three experimental diets containing 5% FM (T2-D2, T2-D3, T2-D4). FO was the only added oil in D1, while a blend of plant oils replaced 58% and 84% of FO in T2-D2, and T2-D3 and T2-D4, respectively. The latter was supplemented with 0.4% BP-70. In a third trial (T3), two groups of fish were fed for 12 and 38 months with D1, D3 and D4 diets of T2. The effects of dietary changes were studied using histochemical, immunohistochemical, molecular and electrophysiological tools. The extreme diet (T2-D3) modified significantly the transcriptomic profile, especially at the anterior intestine, up-regulating the expression of inflammatory markers, in coincidence with a higher presence of granulocytes and lymphocytes in the submucosa, and changing genes involved in antioxidant defences, epithelial permeability and mucus production. Trans-epithelial electrical resistance (Rt) was also decreased (T3-D3). Most of these modifications were returned to control values with the addition of BP-70. None of the experimental diets modified the staining pattern of PCNA, FABP2 or ALPI. These results further confirm the potential of this additive to improve or reverse the detrimental effects of extreme fish diet formulations.
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