ReviewCurrent opinion in ophthalmology2017
Lamina cribrosa in glaucoma.
Review in Current opinion in ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 143 citations in OpenAlex.
- The Pathophysiological Association Between Obstructive Sleep Apnea and Glaucoma: A Current Update.Journal of clinical medicine · 2026Review
- Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma.Translational vision science & technology · 2026Article
- Retinal nerve fibre layer optical texture analysis: retinal nerve fibre bundle defect patterns and the extent of macular involvement across different stages of glaucoma.The British journal of ophthalmology · 2026Article
- Changes in the nonlinear and viscoelastic mechanical properties of the rat lamina cribrosa under chronic high intraocular pressure.Frontiers in bioengineering and biotechnology · 2026Article
- Exploring Structural and Vascular Changes of the Optic Nerve Head After Trabeculectomy in Primary Open-Angle Glaucoma.Vision (Basel, Switzerland) · 2025Article
- Advancing In Vitro Microfluidic Models for Pressure-Induced Retinal Ganglion Cell Degeneration: Current Insights and Future Directions from a Biomechanical Perspective.Micromachines · 2025Article
- Applications of Optical Coherence Tomography in Optic Nerve Head Diseases: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Two-Photon Fabrication of Donor-Specific Human Lamina Cribrosa Models.Translational vision science & technology · 2025Article
- MicroRNA-29b targets ADAM12 and 19 to regulate the extracellular matrix in lamina cribrosa cells.Cell and tissue research · 2025Article
- Cervical Oculopathy: The Cervical Spine Etiology of Visual Symptoms and Eye Diseases-A Hypothesis Exploring Mechanisms Linking the Neck and the Eye.Diagnostics (Basel, Switzerland) · 2025Article
- Drug delivery to the optic nerve: what does the future look like?Therapeutic delivery · 2025Article
- Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.Investigative ophthalmology & visual science · 2025Article
- Pericytes in the optic nerve head.Progress in retinal and eye research · 2025Review
- The molecular mechanisms underlying retinal ganglion cell apoptosis and optic nerve regeneration in glaucoma (Review).International journal of molecular medicine · 2025Review
- Mechanical property changes of glial LC and RGC axons in response to high intraocular pressure.Frontiers in bioengineering and biotechnology · 2025Article
- Role of Microglia in Glaucomatous Pathology.Advances in experimental medicine and biology · 2025Review
- Continuous Wireless Telemetric Measurement of Intraocular Pressure (IOP), Ocular Perfusion Pressure (OPP), and Cerebrospinal Fluid Pressure (CSFP) in Nonhuman Primates (NHPs).Methods in molecular biology (Clifton, N.J.) · 2025Article
- CNN-Based Device-Agnostic Feature Extraction From ONH OCT Scans.Translational vision science & technology · 2024Article
- Development of a novel SupraChoroidal-to-Optic-NervE (SCONE) drug delivery system.Drug delivery · 2024Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis article presents, summarizes, and interprets the most recent advances in the study and understanding of the lamina cribrosa in glaucoma, in the context of previous work. RECENT
findingsThe lamina is an active living structure that responds to strain by changing morphology at the micro-scale and macro-scale in glaucoma. Changes in lamina cribrosa morphology in glaucoma include posteriorization of the laminar insertion into the sclera, increased cupping or depth of the lamina cribrosa, and the development of focal lamina cribrosa defects. These lamina cribrosa changes are associated with disk hemorrhages and visual field damage, and are detectable with clinical imaging techniques such as optical coherence tomography. Glaucomatous changes in the lamina cribrosa are thought to be driven by cellular processes mediated by focal cyclical mechanical strain. Strain is eye specific and mediated by intraocular pressure, cerebrospinal fluid pressure, scleral and lamina cribrosa morphology, and structural stiffness; deleterious lamina cribrosa strains can occur at all levels of mean intraocular pressure. SUMMARY: Laminar morphology is ever changing in health and disease, and recent studies have identified several promising morphological changes that are indicative of glaucoma susceptibility, onset, and progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.