ReviewCurrent opinion in critical care2017
Limiting sedation for patients with acute respiratory distress syndrome - time to wake up.
Review in Current opinion in critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03909854 (Pragmatic Investigation of Volume Targeted Ventilation-1), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic Investigation of Volume Targeted Ventilation-1 (PIVOT-1)
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Noninvasive oxygenation and ventilation strategies for viral acute respiratory failure: a comprehensive systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Pooled it
- Role of Neuromuscular Blocking Agents in Acute Respiratory Distress Syndrome: An Updated Meta-Analysis of Randomized Controlled Trials.Frontiers in pharmacology · 2019Pooled it
- Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial.Critical care (London, England) · 2019Trial
- Consensus statement for managing patients with ARDS in low-resource settings: a Delphi study.Annals of intensive care · 2026Article
- Patient-Self Inflicted Lung Injury (P-SILI): An Insight into the Pathophysiology of Lung Injury and Management.Journal of clinical medicine · 2025Review
- Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the Acute Respiratory Distress Syndrome.Critical care (London, England) · 2022Article
- Electroencephalogram-Based Evaluation of Impaired Sedation in Patients with Moderate to Severe COVID-19 ARDS.Journal of clinical medicine · 2022Article
- Critical role of acute hypoxemia on the cognitive impairment after severe COVID-19 pneumonia: a multivariate causality model analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Early Neurorehabilitation and Recovery from Disorders of Consciousness After Severe COVID-19.Neurocritical care · 2022Article
- Associated Factors of High Sedative Requirements within Patients with Moderate to Severe COVID-19 ARDS.Journal of clinical medicine · 2022Article
- Observation of Curative Effect of Lung Recruitment in Patients with Acute Respiratory Distress Syndrome after Cardiopulmonary Bypass Surgery.Applied bionics and biomechanics · 2022Article
- Review
- Sevoflurane in combination with esketamine is an effective sedation regimen in COVID-19 patients enabling assisted spontaneous breathing even during prone positioning.Anaesthesiology intensive therapy · 2022Article
- Observational
- Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study.BMC pulmonary medicine · 2021Article
- Adjunctive ketamine for sedation in critically ill mechanically ventilated patients: an active-controlled, pilot, feasibility clinical trial.Journal of intensive care · 2021Article
- Clinical Electroencephalography Findings and Considerations in Hospitalized Patients With Coronavirus SARS-CoV-2.The Neurohospitalist · 2021Article
- Spontaneous Versus Controlled Mechanical Ventilation in Patients with Acute Respiratory Distress Syndrome.Current anesthesiology reports · 2021Review
- High sedation needs of critically ill COVID-19 ARDS patients-A monocentric observational study.PloS one · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewCritically ill patients with acute respiratory distress syndrome (ARDS) may require sedation in their clinical care. The goals of sedation in ARDS patients are to improve patient comfort and tolerance of supportive and therapeutic measures without contributing to adverse outcomes. This review discusses the current evidence for sedation management in patients with ARDS. RECENT
findingsDeep sedation strategies should be avoided in the care of patients with ARDS because deep sedation has been associated with increased time on mechanical ventilation, longer ICU and hospital length of stay, and higher mortality in critically ill patients. Adoption of protocol-based, light-sedation strategies is preferred and improves patient outcomes. Although the optimal sedative agent for ARDS patients is unclear, benzodiazepines should be avoided because of associations with oversedation, delirium, prolonged ICU and hospital length of stay, and increased mortality. Minimizing sedation in patients with ARDS facilitates early mobilization and early discharge from the ICU, potentially aiding in recovery from critical illness. Strategies to optimize ventilation in ARDS patients, such as low tidal volume ventilation and high positive end-expiratory pressure can be employed without deep sedation; however, deep sedation is required if patients receive neuromuscular blockade, which may benefit some ARDS patients. Knowledge gaps persist as to whether or not prone positioning and extracorporeal membrane oxygenation can be tolerated with light sedation. SUMMARY: Current evidence supports the use of protocol-based, light-sedation strategies in critically ill patients with ARDS. Further research into sedation management specifically in ARDS populations is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.