ArticleGenes & development2016
A noncanonical auxin-sensing mechanism is required for organ morphogenesis in Arabidopsis.
Article in Genes & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 154 citations in OpenAlex.
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Mutational analyses of an instability domain reveal its conserved role in the regulation of class-B ARF levels inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- VPS13 has an important role in female germline development in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- A Noncanonical Auxin-Sensing Mechanism Uncovered by Screening the Auxin Response Factor 3 Interacting Proteins in Tomato.International journal of molecular sciences · 2026Article
- Cytokinin-responsive P-type cyclins control Arabidopsis radial style morphology.The Plant journal : for cell and molecular biology · 2025Article
- PagMIR166c targets PagECH2 to regulate cambial differentiation into secondary xylem, cell expansion, and lignin deposition via different auxin signaling pathways in poplar stems.The New phytologist · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Article
- Auxin Orchestrates Germ Cell Specification inInternational journal of molecular sciences · 2025Review
- Arabidopsis research in 2030: Translating the computable plant.The Plant journal : for cell and molecular biology · 2025Review
- Conserved roles of ETT and ARF4 in gynoecium development in Brassicaceae with distinct fruit shapes.Development (Cambridge, England) · 2025Article
- Chromatin Immunoprecipitation for Standard, Rare, or Weakly Binding Proteins.Methods in molecular biology (Clifton, N.J.) · 2025Article
- AUXIN RESPONSE FACTOR 2 mediates repression of strawberry receptacle ripening via auxin-ABA interplay.Plant physiology · 2024Article
- Slow and rapid auxin responses in Arabidopsis.Journal of experimental botany · 2024Article
- A 3-component module maintains sepal flatness in Arabidopsis.Current biology : CB · 2024Article
- Divergent Roles of the Auxin Response Factors in Lemongrass (International journal of molecular sciences · 2024Article
- Article
- Arabidopsis transcription factor TCP4 controls the identity of the apical gynoecium.The Plant cell · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Tissue patterning in multicellular organisms is the output of precise spatio-temporal regulation of gene expression coupled with changes in hormone dynamics. In plants, the hormone auxin regulates growth and development at every stage of a plant's life cycle. Auxin signaling occurs through binding of the auxin molecule to a TIR1/AFB F-box ubiquitin ligase, allowing interaction with Aux/IAA transcriptional repressor proteins. These are subsequently ubiquitinated and degraded via the 26S proteasome, leading to derepression of auxin response factors (ARFs). How auxin is able to elicit such a diverse range of developmental responses through a single signaling module has not yet been resolved. Here we present an alternative auxin-sensing mechanism in which the ARF ARF3/ETTIN controls gene expression through interactions with process-specific transcription factors. This noncanonical hormone-sensing mechanism exhibits strong preference for the naturally occurring auxin indole 3-acetic acid (IAA) and is important for coordinating growth and patterning in diverse developmental contexts such as gynoecium morphogenesis, lateral root emergence, ovule development, and primary branch formation. Disrupting this IAA-sensing ability induces morphological aberrations with consequences for plant fitness. Therefore, our findings introduce a novel transcription factor-based mechanism of hormone perception in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.