Evidence map›Paper›PMID 27898207›Full record

Trial reportThe Journal of clinical psychiatry2017

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants: A Randomized Pilot Study.

Anup Sharma, Marna S Barrett, Andrew J Cucchiara, Nalaka S Gooneratne, Michael E Thase

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02616549 phase2completednot on this map

A Randomized Study of a Comprehensive Yoga Intervention for Patients With Major Depressive Disorder With Incomplete Response to Antidepressants

TypeinterventionalSponsorUniversity of PennsylvaniaRan2014 to 2015Enrolled25ConditionsMajor Depressive DisorderArmsSudarshan Kriya Yoga
NCT05468112 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Improving Wellbeing of SHP Personnel at UAB

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2024 to 2025Enrolled0ConditionsStress, PsychologicalArmsSKY Meditation and Mindfulness
NCT07220421 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluate Foundational Wellness Programs to Help Reduce Clinician Burnout and Improve Professional Fulfilment in Health Care Professionals.

TypeinterventionalSponsorLancaster General HospitalRan2025 to 2026Enrolled180ConditionsBurnout, Professional, Stress, Psychological, Stress, Physiological, Psychological Well-BeingArmsSudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation, Health Education Program (HEP)
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  12. Therapeutic potential of slow pranayama in anxiety.Journal of family medicine and primary care · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Anup SharmaDepartment of Psychiatry, University of Pennsylvania School of Medicine, 10th Floor, Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104. anup@mail.med.upenn.edu.
Marna S BarrettDepartment of Psychiatry, University of Pennsylvania, Philadelphia, USA.
Andrew J CucchiaraDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, USA.
Nalaka S GooneratneDivision of Geriatric Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Michael E ThaseDepartment of Psychiatry, University of Pennsylvania, Philadelphia, USA.

Funding

Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
PSYCHOBIOLOGICAL CORRELATES OF RECOVERY IN DEPRESSION-IIR01MH041884 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THASE, MICHAEL E · 1987 to 1998
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NCATS NIH HHS UL1 TR000003NCRR NIH HHS M01 RR000056NIMH NIH HHS R01 MH041884
6 · The paper itself

Abstract

objectiveTo evaluate feasibility, efficacy, and tolerability of Sudarshan Kriya yoga (SKY) as an adjunctive intervention in patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment.

methodsPatients with MDD (defined by DSM-IV-TR) who were depressed despite ≥ 8 weeks of antidepressant treatment were randomized to SKY or a waitlist control (delayed yoga) arm for 8 weeks. The primary efficacy end point was change in 17-item Hamilton Depression Rating Scale (HDRS-17) total score from baseline to 2 months. The key secondary efficacy end points were change in Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) total scores. Analyses of the intent-to-treat (ITT) and completer sample were performed. The study was conducted at the University of Pennsylvania between October 2014 and December 2015.

resultsIn the ITT sample (n = 25), the SKY arm (n = 13) showed a greater improvement in HDRS-17 total score compared to waitlist control (n = 12) (-9.77 vs 0.50, P = .0032). SKY also showed greater reduction in BDI total score versus waitlist control (-17.23 vs -1.75, P = .0101). Mean changes in BAI total score from baseline were significantly greater for SKY than waitlist (ITT mean difference: -5.19; 95% CI, -0.93 to -9.34; P = .0097; completer mean difference: -6.23; 95% CI, -1.39 to -11.07; P = .0005). No adverse events were reported.

conclusionsResults of this randomized, waitlist-controlled pilot study suggest the feasibility and promise of an adjunctive SKY-based intervention for patients with MDD who have not responded to antidepressants.

trial registrationClinicalTrials.gov identifier: NCT02616549.

Indexed as

MeditationRespirationYogaAdolescentAdultAgedAntidepressive AgentsCase-Control StudiesCombined Modality TherapyDepressive Disorder, Treatment-ResistantFeasibility StudiesFemaleHumansMajor Depressive DisorderMaleMiddle AgedAntidepressive Agents

Identifiers

PMID27898207
PMCPMC5272872

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.