ArticleScientific reports2016
Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Article
- ZnT7 RNAi favors RafOncogene · 2021Article
- Wallenda-Nmo Axis Regulates Growth via Hippo Signaling.Frontiers in cell and developmental biology · 2021Article
- Mud Loss Restricts Yki-Dependent Hyperplasia inJournal of developmental biology · 2020Article
- Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling inDevelopment (Cambridge, England) · 2018Article
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5 authors at 2 institutions in 2 countries.
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Abstract
Compartment boundaries prevent cell populations of different lineage from intermingling. In many cases, compartment boundaries are associated with morphological folds. However, in the Drosophila wing imaginal disc, fold formation at the anterior/posterior (A/P) compartment boundary is suppressed, probably as a prerequisite for the formation of a flat wing surface. Fold suppression depends on optomotor-blind (omb). Omb mutant animals develop a deep apical fold at the A/P boundary of the larval wing disc and an A/P cleft in the adult wing. A/P fold formation is controlled by different signaling pathways. Jun N-terminal kinase (JNK) and Yorkie (Yki) signaling are activated in cells along the fold and are necessary for the A/P fold to develop. While JNK promotes cell shape changes and cell death, Yki target genes are required to antagonize apoptosis, explaining why both pathways need to be active for the formation of a stable fold.
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