SynthesisScientific reports2016
The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- The prevalence of antibiotic-resistant Clostridium species in Iran: a meta-analysis.Pathogens and global health · 2019Pooled it
- Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Burden of Clostridioides difficile infection in China, 1990-2021: an analysis based on the global burden of disease study 2021.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Molecular epidemiology ofMicrobiology spectrum · 2026Article
- Clostridioides difficile as a Zoonotic and Foodborne Pathogen: Reviewing the Global Evidence and South African Data.MicrobiologyOpen · 2026Review
- Nasogastric Delivery of Fecal Microbiota Transplantation for the Treatment of FulminantJGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Abundant geographical divergence of Clostridioides difficile infection in China: a prospective multicenter cross-sectional study.BMC infectious diseases · 2025Article
- Epidemiology and genetic characteristics ofPeerJ · 2025Article
- Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigateFrontiers in chemistry · 2025Article
- Genomic epidemiology ofEmerging microbes & infections · 2024Article
- Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi'an, China.BMC microbiology · 2024Article
- [Analysis ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Antimicrobial Resistance and Associated Risk Factors forJournal of tropical medicine · 2024Article
- Genomic Epidemiology ofInfection and drug resistance · 2024Article
- Development and evaluation of a rapid visual loop-mediated isothermal amplification assay for thePeerJ · 2024Article
- Impact of antibiotic prophylaxis on gut microbiota in colorectal surgery: insights from an Eastern European stewardship study.Frontiers in cellular and infection microbiology · 2024Article
- Analysis of risk factors for community-acquiredTranslational pediatrics · 2023Article
- An epidemiological surveillance study (2021-2022): detection of a high diversity of Clostridioides difficile isolates in one tertiary hospital in Chongqing, Southwest China.BMC infectious diseases · 2023Article
- Genomic Epidemiology and Antimicrobial Resistance Profiles ofInfection and drug resistance · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been widely reported that the incidence and severity of Clostridium difficile infection (CDI) have increased dramatically in North America and Europe. However, little is known about CDI in Mainland China. In this study, we aimed to investigate the incidence of CDI and the main epidemic and drug-resistant strains of C. difficile in Mainland China through meta-analysis of related studies published after the year 2010. A total of 51 eligible studies were included. The pooled incidence of toxigenic C. difficile among patients with diarrhoea was 14% (95% CI = 12-16%). In Mainland China, ST-37 and ST-3 were the most prevalent strains; fortunately, hypervirulent strains, such as ST-1 (BI/NAP1/027) and ST-11 (RT 078), have only occurred sporadically to date. The rates of C. difficile resistance to ciprofloxacin (98.3%; 95% CI = 96.9-99.7%), clindamycin (81.7%; 95% CI = 76.1-87.3%) and erythromycin (80.2%; 95% CI = 73.5-86.9%) are higher than in other counties; however, none of the C. difficile isolates reported in Mainland China were resistant to metronidazole (n/N = 0/960), vancomycin (n/N = 0/960), tigecycline (n/N = 0/41) or piperacillin/tazobactam(n/N = 0/288).
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