ArticleNature communications2016
Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 26 citations in OpenAlex.
- Mixed Evidence that Dosage Sensitive Genes Drive Global Dosage Compensation in Flour Beetles.Genome biology and evolution · 2026Article
- Evolutionary Dynamics of Dosage Compensation and Sex-biased Gene Expression in Morabine Grasshopper Vandiemenella viatica.Genome biology and evolution · 2026Article
- An Extension of Muller's Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.Molecular biology and evolution · 2025Article
- Reduced Efficacy of Selection on a Young Z Chromosome Region of Schistosoma japonicum.Genome biology and evolution · 2025Article
- Evolution of sex-biased genes inEcology and evolution · 2024Article
- Slower-X: reduced efficiency of selection in the early stages of X chromosome evolution.Evolution letters · 2023Article
- Shared evolutionary trajectories of three independent neo-sex chromosomes inGenome research · 2021Article
- Article
- A-to-I RNA editing in honeybees shows signals of adaptation and convergent evolution.iScience · 2021Article
- Sex Chromosome Evolution in Muscid Flies.G3 (Bethesda, Md.) · 2020Article
- Widespread gene duplication and adaptive evolution in the RNA interference pathways of the Drosophila obscura group.BMC evolutionary biology · 2019Article
- An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera.PLoS genetics · 2018Article
- Gene-by-Gene or Localized Dosage Compensation on the Neo-X Chromosome in Drosophila miranda.Genome biology and evolution · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Y chromosomes often degenerate via the accumulation of pseudogenes and transposable elements. By contrast, little is known about X-chromosome degeneration. Here we compare the pseudogenization process between genes on the neo-sex chromosomes in Drosophila miranda and their autosomal orthologues in closely related species. The pseudogenization rate on the neo-X is much lower than the rate on the neo-Y, but appears to be higher than the rate on the orthologous autosome in D. pseudoobscura. Genes under less functional constraint and/or genes with male-biased expression tend to become pseudogenes on the neo-X, indicating the accumulation of slightly deleterious mutations and the feminization of the neo-X. We also find a weak trend that the genes with female-benefit/male-detriment effects identified in D. melanogaster are pseudogenized on the neo-X, implying the masculinization of the neo-X. These observations suggest that both X and Y chromosomes can degenerate due to a complex suite of evolutionary forces.
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