Evidence map›Paper›PMID 27897054›Full record

ArticleAIDS research and human retroviruses2017

High Levels of Inflammatory Cytokines in the Reproductive Tract of Women with BV and Engaging in Intravaginal Douching: A Cross-Sectional Study of Participants in the Women Interagency HIV Study.

Maria L Alcaide, Violeta J Rodriguez, Megan R Brown, Suresh Pallikkuth, Kristopher Arheart, Octavio Martinez, Margaret Roach, Raina N Fichorova, Deborah L Jones, Savita Pahwa and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maria L Alcaide1 Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida.
Violeta J Rodriguez2 Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine , Miami, Florida.
Megan R Brown2 Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine , Miami, Florida.
Suresh Pallikkuth3 Department of Microbiology and Immunology, University of Miami Miller School of Medicine , Miami, Florida.
Kristopher Arheart4 Department of Epidemiology and Public Health, University of Miami Miller School of Medicine , Miami, Florida.
Octavio Martinez3 Department of Microbiology and Immunology, University of Miami Miller School of Medicine , Miami, Florida.
Margaret Roach3 Department of Microbiology and Immunology, University of Miami Miller School of Medicine , Miami, Florida.
Raina N Fichorova5 Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.
Deborah L Jones2 Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine , Miami, Florida.
Savita Pahwa3 Department of Microbiology and Immunology, University of Miami Miller School of Medicine , Miami, Florida.
Margaret A Fischl1 Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida.
University of Miami · USBrigham and Women's Hospital · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Miami Womens Interagency HIV Study WIHSU01AI103397 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FISCHL, MARGARET A, METSCH, LISA R · 2013 to 2018
$9.6M
Vaginal practices in HIV positive women in Zambia a bio-behavioral interventionK23HD074489 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALCAIDE, MARIA LUISA · 2012 to 2016
$532k
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NIAID NIH HHS P30 AI073961NIAID NIH HHS U01 AI103397NICHD NIH HHS K23 HD074489
6 · The paper itself

Abstract

High levels of inflammatory cytokines in the genital tract suggest mucosal vulnerability and increased risk of HIV and sexually transmitted infection (STI) acquisition. Intravaginal douching is associated with bacterial vaginosis (BV) in women in the United States, and both douching and BV are linked to HIV and STI acquisition. This study evaluates inflammatory cytokines in the genital tract to increase understanding of the effects of both BV and intravaginal douching to the vaginal mucosa. A cross-sectional study of participants in the Miami WIHS investigated 72 reproductive age women (45 HIV

Indexed as

AdolescentAdultCross-Sectional StudiesCytokinesFemaleHIV InfectionsHumansMiddle AgedMucous MembraneSurveys and QuestionnairesUnited StatesVaginaVaginal DouchingVaginosis, BacterialYoung AdultCytokinesbacterial vaginosisgenital cytokinesvaginal doucheswomen and HIV

Identifiers

PMID27897054
PMCPMC5372759
OpenAlexW2575620371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.