Evidence map›Paper›PMID 27896967›Full record

ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2017

METHODS TO ENSURE THE REPRODUCIBILITY OF BIOMEDICAL RESEARCH.

Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis

Abstract read
In one paragraph

Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Konrad J KarczewskiMassachusetts General Hospital, Boston, MA, USA2Broad Institute, Cambridge, MA, USA, konradjkarczewski@gmail.com.
Nicholas P Tatonetti
Arjun K Manrai
Chirag J Patel
C Titus Brown
John P A Ioannidis

Funding

Biomedical Data Translator Technical Feasibility Assessment and Architecture DesignOT3TR002027 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DUMONTIER, MICHEL, TATONETTI, NICHOLAS P · 2016 to 2019
$2.7M
Drug Effect Discovery Through Data Mining and Integrative Chemical BiologyR01GM107145 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TATONETTI, NICHOLAS P · 2014 to 2018
$2.5M
NCATS NIH HHS OT3 TR002027NIGMS NIH HHS R01 GM107145
6 · The paper itself

Abstract

Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses. In our opinion, the concept of data hoarding not only runs contrary to the spirit of, but also hinders scientific progress. Scientific research is meant to seek objective truth, rather than promote a personal agenda, and the only way to do so is through maximum transparency and reproducibility, no matter who is using the data….

Identifiers

PMID27896967
PMCPMC5984201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.